Elucidation of renin-angiotensin system roles in osteocyte and development of novel osteogenic medication.
Project/Area Number |
26713048
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Partial Multi-year Fund |
Research Field |
Orthopaedic surgery
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
Ochi Hiroki 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (30582283)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2015: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2014: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
|
Keywords | 骨細胞 / レニンアンギオテンシン系 / 骨代謝 / レニン・アンジオテンシン / RAS |
Outline of Final Research Achievements |
In this study, we evaluated the significance of the renin angiotensin system in osteocytes by using osteocyte-specific RAS related gene deficient mice. These conditional knockout mice showed excessive bone mass in cortical bone. Osteoblast activities in cortical bone were significantly increased by bone morphological analysis. These findings suggest that RAS related gene in osteocyte regulates osteoblast function negatively and then maintains bone remodeling.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] WNK4 is an Adipogenic Factor and Its Deletion Reduces Diet-Induced Obesity in Mice.2017
Author(s)
Takahashi D, Mori T, Sohara E, Tanaka M, Chiga M, Inoue Y, Nomura N, Zeniya M, Ochi H, Takeda S, Suganami T, Rai T, Uchida S.
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Journal Title
EBioMedicine
Volume: 18
Pages: 118-27
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Bone Resorption Is Regulated by Circadian Clock in Osteoblasts.2017
Author(s)
Takarada T, Xu C, Ochi H, Nakazato R, Yamada D, Nakamura S, Kodama A, Shimba S, Mieda M, Fukasawa K, Ozaki K, Iezaki T, Fujikawa K, Yoneda Y, Numano R, Hida A, Tei H, Takeda S, Hinoi E.
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Journal Title
J Bone Miner Res.
Volume: 32
Issue: 4
Pages: 872-881
DOI
Related Report
Peer Reviewed
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