The mechanism of generation of reactive oxygen species and oxidative neuronal injury induced by methylmercury
Project/Area Number |
26740024
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Risk sciences of radiation and chemicals
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Research Institution | Hiroshima University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | メチル水銀 / 活性酸素 / 酸化ストレス / ミトコンドリア / MRI / 神経毒性 |
Outline of Final Research Achievements |
The purpose of this study is to reveal the mechanism of oxidative neuronal injury induced by methylmercury. Reactive oxygen species (ROS) derived from mitochondria were shown to be involved in neurotoxicity induced by methylmercury using mitochondrial DNA depleted SH-SY5Y cells. Brain region specific oxidation was detected in mice administered with methylmercury. The relationships between region specific generation of ROS and behavior disorder induced by methylmercury will be examined in the future.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1.2014
Author(s)
Baba T, Otake H, Sato T, Miyabayashi K, Shishido Y, Wang CY, Shima Y, Kimura H, Yagi M, Ishihara Y, Hino S, Ogawa H, Nakao M, Yamazaki T, Kang D, Ohkawa Y, Suyama M, Chung BC, Morohashi K.
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Journal Title
Nat. Commun.
Volume: 5
Pages: 3634-3634
NAID
Related Report
Peer Reviewed
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