| Project/Area Number |
26740025
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
Komoike Yuta 東京女子医科大学, 医学部, 講師 (70386556)
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| Research Collaborator |
MATSUMURA Kenichi 東京女子医科大学, 医学部, 実験補助員
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | ゼブラフィッシュ / 環境毒性学 / 小胞体ストレス応答 / アクリルアミド |
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| Outline of Final Research Achievements |
Acrylamide has recently been recognized as an immediate hazardous chemical worldwide. In this study, this applicant focused on the toxicity of acrylamide, especially on the mechanisms underlying expression of acrylamide-induced neurotoxicity. The applicant revealed that exposure of human neuroblastoma cells to acrylamide increases accumulation of reactive oxygen species (ROS) and these ROS evoke endoplasmic reticulum (ER) stress response followed by cell death including apoptosis. The applicant also showed that exposure of zebrafish larvae to acrylamide induces expression of the gene encoding ER stress response-dependent proapoptotic factor in the brain, apoptotic death of the brain cells, and dramatic disruption of the brain structure. These findings were reported in an original article and domestic conferences four times.
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