| Project/Area Number |
26750158
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Shinshu University |
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Principal Investigator |
YOSHIDA Hiroaki 信州大学, 学術研究院繊維学系, 助教 (40727913)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 感熱応答性高分子 / ゾルーゲル転移 / ハイドロゲル / 高強度ゲル / 可逆性 / 細胞足場材料 / 三次元組織体 / 再生医療 / バイオマテリアル / ヒドロキシブチルキトサン / 三次元細胞組織体 |
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| Outline of Final Research Achievements |
In this research, we synthesized chitosan derivatives in order to develop thermally-removal hydrogel scaffolds under cell culture conditions. The polymer solution in water was quickly gelled at body temperature, and the formed hydrogels was very touch, seemed like plastics rather than hydrogels. However, the hydrogels could easily return to the solution by cooling at 4oC. These results clearly show the creation of the new material “polymeric solid materials which can dissolve by lowering temperature”.
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