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Creation of Thermally-Dissolvable Hydrogels under Cell Culture Conditions

Research Project

Project/Area Number 26750158
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionShinshu University

Principal Investigator

YOSHIDA Hiroaki  信州大学, 学術研究院繊維学系, 助教 (40727913)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords感熱応答性高分子 / ゾルーゲル転移 / ハイドロゲル / 高強度ゲル / 可逆性 / 細胞足場材料 / 三次元組織体 / 再生医療 / バイオマテリアル / ヒドロキシブチルキトサン / 三次元細胞組織体
Outline of Final Research Achievements

In this research, we synthesized chitosan derivatives in order to develop thermally-removal hydrogel scaffolds under cell culture conditions. The polymer solution in water was quickly gelled at body temperature, and the formed hydrogels was very touch, seemed like plastics rather than hydrogels. However, the hydrogels could easily return to the solution by cooling at 4oC. These results clearly show the creation of the new material “polymeric solid materials which can dissolve by lowering temperature”.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014 Other

All Presentation (7 results) Remarks (3 results)

  • [Presentation] 感熱応答高分子ハイドロゲルの立体造形による3次元組織構築2016

    • Author(s)
      高村寧・島史明・吉田裕安材・明石満
    • Organizer
      日本化学会第96回春季年会
    • Place of Presentation
      同志社大学(京都府京田辺市)
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 温度応答性高分子を用いた高強度ハイドロゲルの作製2015

    • Author(s)
      小野靖貴、吉田裕安材
    • Organizer
      第64回高分子討論会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] 感熱応答性高分子のゾルーゲル転移を利用した三次元組織の構築2015

    • Author(s)
      吉田裕安材、明石満
    • Organizer
      第95回日本化学会春季年会
    • Place of Presentation
      日本大学
    • Year and Date
      2015-03-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Detailed Investigation of Thermosensitive Chitosan Having Hydroxybutyl Moieties2014

    • Author(s)
      Piyapakorn Phassamon、吉田裕安材、明石満
    • Organizer
      第63回高分子討論会
    • Place of Presentation
      長崎大学
    • Year and Date
      2014-09-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 可逆的なゾルーゲル転移を利用した三次元組織の構築2014

    • Author(s)
      吉田裕安材、明石満
    • Organizer
      第63回高分子討論会
    • Place of Presentation
      長崎大学
    • Year and Date
      2014-09-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 感熱応答性高分子ハイドロゲルの三次元プリンティング2014

    • Author(s)
      吉田裕安材、明石満
    • Organizer
      第63回高分子討論会
    • Place of Presentation
      長崎大学
    • Year and Date
      2014-09-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 細胞培養基材としての感熱応答溶解性ハイドロゲルの作製2014

    • Author(s)
      吉田裕安材、明石満
    • Organizer
      第63回高分子学会年次大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2014-05-29
    • Related Report
      2014 Research-status Report
  • [Remarks] 信州大学繊維学部吉田研究室HP

    • URL

      http://hyoshidalab.wix.com/home

    • Related Report
      2015 Annual Research Report
  • [Remarks] 信州大学繊維学部吉田研究室ホームページ

    • URL

      http://hyoshidalab.wix.com/home

    • Related Report
      2014 Research-status Report
  • [Remarks] 信州大学繊維学部研究者総覧

    • URL

      http://soar-rd.shinshu-u.ac.jp/profile/ja.gUfNHVcN.html

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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