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The role of the olivo-cerebellar input in motor control

Research Project

Project/Area Number 26750238
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Developmental mechanisms and the body works
Research InstitutionChiba Institute of Technology (2016)
Teikyo Heisei University (2015)
The University of Tokyo (2014)

Principal Investigator

SATO Yamato  千葉工業大学, 創造工学部, 准教授 (40637914)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords下オリーブ核ー登上線維系 / 運動制御 / 小脳 / 下オリーブ核-登上線維系 / 姿勢制御 / 下オリーブ核―登上線維系
Outline of Final Research Achievements

Climbing fibers (CFs) which originate from the inferior olive (IO), these synaptic actions to the Purkinje cells are necessary for the synaptic plasticity in the cerebellum and motor learning. However, it is unknown that role of CFs input in motor control. The purpose of this study was to investigate the role of CFs input in motor control. The following results were obtained focusing on posture control which is considered as basis of motor control. ① It was constructed a hindlimb posture experimental environment for the rat which is a quadruped animal. ② It was obtained a data of IO animal which lesions to the olivo-cerebellar pathway during upright by hindlimb.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015 2014

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Progressive impairment of cerebellar mGluR signalling and its therapeutic potential for cerebellar ataxia in spinocerebellar ataxia type 1 model mice.2017

    • Author(s)
      Shuvaev AN, Hosoi N, Sato Y, Yanagihara D, Hirai H.
    • Journal Title

      The Journal of Physiology

      Volume: 595(1) Issue: 1 Pages: 141-164

    • DOI

      10.1113/jp272950

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effect of inactivation of the intermediate cerebellum on overground locomotion in the rat : a comparative study of the anterior and posterior lobes2014

    • Author(s)
      S. Aoki, Y. Sato, and D. Yanagihara
    • Journal Title

      Neurosci. Lett

      Volume: (in press) Pages: 22-27

    • DOI

      10.1016/j.neulet.2014.05.027

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Lesions to the olivo-cerebellar pathway disturbed a toe trajectory during stepping over an obstacle in rat2016

    • Author(s)
      Yamato Sato, Sho Aoki, Dai Yanagihara
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      San Diego, USA.
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Intersegmental coordination of bipedally standing rat.2016

    • Author(s)
      Yota Sato, Tetsuro Funato, Dai Yanagihara, Yamato Sato, Soichiro Fujiki, Shinya Aoi, and Kazuo Tsuchiya.
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      San Diego, USA.
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of the intersegmental coordination of standing rat.2016

    • Author(s)
      Tetsuro Funato, Yota Sato, Dai Yanagihara, Yamato Sato, Soichiro Fujiki, Shinya Aoi, Kazuo Tsuchiya.
    • Organizer
      The 1st International Symposium on Embodied-Brain Systems Science
    • Place of Presentation
      東京大学, Tokyo, Japan
    • Year and Date
      2016-05-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamical model of the body sway of bipedally standing rat with olivo-cerebellar dysfunction2015

    • Author(s)
      Noro S., Funato T., Sato Y., Sato Y., Yanagihara D., Aoi S., Tsuchiya K.
    • Organizer
      International symposium on Micro-NanoMechatronics and Human Science
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2015-11-23
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of the body sway of bipedally standing rat with olivo-cerebellar dysfunction2015

    • Author(s)
      Noro S., Funato T., Sato Y., Sato Y., Yanagihara D., Aoi S., Tsuchiya K.
    • Organizer
      The 37th Annual International conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Milano, Italy
    • Year and Date
      2015-08-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Measuring body sway of bipedally standing rat and quantitative evaluation of its postural control2015

    • Author(s)
      Sato Y., Funato T., Yanagihara D., Sato Y., Aoi S., Fujiki S., Nakano K., Tsuchiya K.
    • Organizer
      The 37th Annual International conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Milano, Italy
    • Year and Date
      2015-08-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ラットモデルを用いた歩行中の障害物回避動作における延髄下オリーブ核ー登上線維系破壊の影響2015

    • Author(s)
      佐藤 和、境 和久、青木 祥、端川 勉、柳原 大
    • Organizer
      第27回自律分散システム・シンポジウム
    • Place of Presentation
      東京理科大学神楽坂キャンパス(東京都新宿区)
    • Year and Date
      2015-01-22 – 2015-01-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 神経疾患に伴う姿勢制御系の変容解明のためのラットの直立実験環境の構築2015

    • Author(s)
      佐藤陽太、船戸徹郎、柳原 大、佐藤 和 他4名
    • Organizer
      第27回自律分散システム・シンポジウム
    • Place of Presentation
      東京理科大学神楽坂キャンパス(東京都新宿区)
    • Year and Date
      2015-01-22 – 2015-01-23
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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