Longitudinal association between family caregiver burden and patients' symptoms.

• Project/Area Number: 26780306
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Social welfare and social work studies
• Research Institution: Kumamoto University
• Principal Investigator: Koyama Asuka 熊本大学, 大学院生命科学研究部(医), 助教 (50710670)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 認知症 / 介護負担 / BPSD / 介護ストレス / 介護負担感 / 意味性認知症 / 前頭側頭葉変性症 / 希死念慮

Outline of Final Research Achievements

In a three-year follow-up study, we found that higher caregiver burden affected patients' higher Behavioral and Psychological Symptoms of dementia (BPSD).Our result shows that support for caregivers have a positive effect not only for caregivers but also for patients.
We also examined 1) the association between suicidal ideation among patients with dementia and caregiver burden, 2)mental health status among dementia caregivers compared to community residents, and 3) caregiver burden among patients with semantic dementia.

Research Products

• [Journal Article] Caregiver burden in semantic dementia with right- and left-sided predominant cerebral atrophy and in behavioral variant frontotemporal dementia. (2018)
  • Author(s): Koyama A, Hashimoto M, Fukuhara R, Ichimi N, Takasaki A, Matsushita M, Ishikawa T, Tanaka H, Miyagawa Y, Ikeda M.
  • Journal Title: Dement Geriatr Cogn Dis Extra Volume: -
  • Peer Reviewed / Open Access
• [Journal Article] Why do people with dementia pretend to know the correct answer? A qualitative study on the behaviour of toritsukuroi to keep up appearances, Psychogeriatrics (2017)
  • Author(s): Matsushita M., Yatabe Y., Koyama A., Ueno Y., Ijichi D., Ikezaki H., Hashimoto M., Furukawa N., Ikeda M.
  • Journal Title: Psychogeriatrics Volume: 4 Issue: 6 Pages: 001-001
  • DOI: 10.1111/psyg.12253
  • Peer Reviewed
• [Journal Article] Mental health among younger and older caregivers of dementia patients. (2016)
  • Author(s): Koyama A, Matsushita M, Hashimoto M, Fujise N, Ishikawa T, Tanaka H, Hatada Y, Miyagawa Y, Hotta M, Ikeda M
  • Journal Title: Psychogeriatrics Volume: in press Issue: 2 Pages: 108-114
  • DOI: 10.1111/psyg.12200
  • Peer Reviewed / Open Access
• [Journal Article] Malnutrition in Alzheimer's Disease, Dementia with Lewy Bodies, and Frontotemporal Lobar Degeneration: Comparison Using Serum Albumin, Total Protein, and Hemoglobin Level. (2016)
  • Author(s): Koyama A, Hashimoto M, Tanaka H, Fujise N, Matsushita M, Miyagawa Y, Hatada Y, Fukuhara R, Hasegawa N, Todani S, Matsukuma K, Kawano M, Ikeda M.
  • Journal Title: PLoS One Volume: 11
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cross-cultural study of caregiver burden for Alzheimer’s disease in Japan and Taiwan: Result from ｄementia ｒesearch in Kumamoto and Tainan (DeReKaT) (2016)
  • Author(s): Matsushita M, Pai MC, Jhou BS, Koyama A, Ikeda M
  • Journal Title: International Psychogeriatrics Volume: 28 Issue: 7 Pages: 1-8
  • DOI: 10.1017/s104161021600003x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cross-cultural study of caregiver burden for Alzheimer's disease in Japan and Taiwan: result from Dementia Research in Kumamoto and Tainan (DeReKaT). (2016)
  • Author(s): Matsushita M, Pai MC, Jhou CY, Koyama A, Ikeda M.
  • Journal Title: International Psychogeriatrics Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Comparisons of prevalence and related factors of depression in middle-aged adults between urban and rural populations in Japan. (2015)
  • Author(s): Fujise N, Abe Y, Fukunaga R, Nakagawa Y, Nishi Y, Koyama A, Ikeda M
  • Journal Title: J Affect Disord Volume: 190 Pages: 772-776
  • DOI: 10.1016/j.jad.2015.11.020
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comparing the driving behaviours of individuals with frontotemporal lobar degeneration and those with Alzheimer's disease. (2015)
  • Author(s): Fujito R, Kamimura N, Ikeda M, Koyama A, Shimodera S, Morinobu S, Inoue S.
  • Journal Title: Psychogeriatrics Volume: 未定 Issue: 1 Pages: 27-33
  • DOI: 10.1111/psyg.12115
  • Peer Reviewed / Open Access
• [Journal Article] 精神科病院の長期在院患者の退院動態と関連要因． (2015)
  • Author(s): 河野 稔明, 白石 弘巳, 立森 久照, 小山 明日香, 長沼 洋一, 竹島 正
  • Journal Title: 精神神経学雑誌 Volume: 117 Pages: 713-729
  • Peer Reviewed
• [Journal Article] Suicidal ideation and related factors among dementia patients. (2015)
  • Author(s): Koyama A, Fujise N, Matsushita M, Ishikawa T, Hashimoto M, Ikeda M.
  • Journal Title: J Affect Disord Volume: 178 Pages: 66-70
  • DOI: 10.1016/j.jad.2015.02.019
  • Peer Reviewed / Open Access
• [Journal Article] The relationship between Post-stroke depression and physical recovery. (2015)
  • Author(s): Matsuzaki S, Hashimoto M, Yuuki S, Koyama A, Hirata Y, Ikeda M.
  • Journal Title: Journal of affective disorders Volume: 176 Pages: 56-60
  • DOI: 10.1016/j.jad.2015.01.020
  • Peer Reviewed / Open Access
• [Journal Article] Is sense of coherence helpful in coping with caregiver burden for dementia? (2014)
  • Author(s): Matsushita M, Ishikawa T, Koyama A, Hasegawa N, Ichimi N, Yano H, Hashimoto M, Fujise N, Ikeda M.
  • Journal Title: Psychogeriatrics Volume: 14 Issue: 2 Pages: 87-92
  • DOI: 10.1111/psyg.12050
  • Peer Reviewed / Open Access
• [Journal Article] Sleep duration and its association with sleepiness and depression in "ronin-sei" preparatory school students. (2014)
  • Author(s): Matsushita M, Koyama A, Ushijima H, Mikami A, Katsumata Y, Kikuchi Y, Ichimi N, Jono T, Fujise N, Ikeda M.
  • Journal Title: Asian Journal of Psychiatry Volume: 9 Pages: 61-66
  • DOI: 10.1016/j.ajp.2014.01.006
  • Peer Reviewed
• [Journal Article] Item non-response on self-reported depression screening questionnaire among community-dwelling elderly. (2014)
  • Author(s): Koyama A, Fukunaga R, Abe Y, Nishi Y, Fujise N, Ikeda M.
  • Journal Title: Journal of Affective Disorders Volume: 162 Pages: 30-33
  • DOI: 10.1016/j.jad.2014.03.022
  • Peer Reviewed
• [Journal Article] Patient-Related Factors Associated With Depressive State in Caregivers of Patients With Dementia at Home. (2014)
  • Author(s): Hasegawa N, Hashimoto M, Koyama A, Ishikawa T, Yatabe Y, Honda K, Yuuki S, Araki K, Ikeda M.
  • Journal Title: J Am Med Dir Assoc. Volume: 15(5) Issue: 5 Pages: 371.e15-371.e18
  • DOI: 10.1016/j.jamda.2014.02.007
  • Peer Reviewed / Open Access
• [Journal Article] 8. Association between depression, examination-related stressors, and sense of coherence: the Ronin-Sei study. (2014)
  • Author(s): Koyama A, Matsushita M, Ushijima H, Jono T, Ikeda M.
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 68 Issue: 6 Pages: 441-447
  • DOI: 10.1111/pcn.12146
  • Peer Reviewed
• [Presentation] アルツハイマー病患者家族の介護負担感がその後のBPSDに及ぼす影響 -3年間の縦断データを用いた分析- (2017)
  • Author(s): 小山明日香, 橋本衛, 松下正輝, 池田学．
  • Organizer: 第32回日本老年精神医学会
• [Presentation] Four-Year Progression of Cognitive Function in a Clinical Sample of Patients with Alzheimer’s Disease and Amnestic Mild Cognitive Impairment (2016)
  • Author(s): Koyama A, Hashimoto M, Fukuhara R, Ishikawa T, Ikeda M
  • Organizer: 2016 IPA Asian Regional Meeting
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2016-12-09
  • Int'l Joint Research
• [Presentation] ADとDLBにおける生活行為障害の特徴と自立の割合に関する研究． (2016)
  • Author(s): 堀田牧、小山明日香、村田美希、吉浦和宏、田平隆行、田中響、石川智久、橋本衛、池田学．
  • Organizer: 第35回日本認知症学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-12-01
• [Presentation] レビー小体型認知症の幻視の重症度と負担度に関する研究． (2016)
  • Author(s): 上野由紀子、小山明日香、石川智久、橋本衛、池田学．
  • Organizer: 第40回日本神経心理学会学術集会
  • Place of Presentation: 熊本
  • Year and Date: 2016-09-15
• [Presentation] 若年性アルツハイマー病に対する集団療法と家族心理教育を組み合わせた外来支援プログラムの実践． (2016)
  • Author(s): 堀田牧、小山明日香、橋本衛、池田学．
  • Organizer: 第50回日本作業療法学会
  • Place of Presentation: 札幌
  • Year and Date: 2016-09-08
• [Presentation] 血管性認知症の日常生活能力の変遷． (2016)
  • Author(s): 吉浦和宏、堀田牧、小山明日香、橋本衛、池田学．
  • Organizer: 第50回日本作業療法学会
  • Place of Presentation: 札幌
  • Year and Date: 2016-09-08
• [Presentation] Characteristics of caregiver burden among patients with mild frontotemporal lobar degeneration: Comparisons between behavioral variants of frontotemporal dementia and semantic dementia with right- and left-sided predominant cerebral atrophy. (2016)
  • Author(s): Koyama A, Fukuhara R, Miyagawa Y, Hotta M, Hashimoto M, Ikeda M.
  • Organizer: 10th International Conference on Frontotemporal Dementias
  • Place of Presentation: Munich, Germany
  • Year and Date: 2016-08-31
  • Int'l Joint Research
• [Presentation] Depression symptoms in patients with frontotemporal labor degeneration. (2016)
  • Author(s): Hashimoto M, Fukuhara R, Kaneda K, Koyama A, Ikeda M.
  • Organizer: 10th International Conference on Frontotemporal Dementias
  • Place of Presentation: Munich, Germany
  • Year and Date: 2016-08-31
  • Int'l Joint Research
• [Presentation] Relationship between cognitive declines and independency in the activities of daily living in patients with frontotemporal labor degeneration. (2016)
  • Author(s): Hotta M, Hashimoto M, Fukuhara R, Koyama A, Murata M, Yoshiura K, Ishikawa T, Tanaka H, Ikeda M.
  • Organizer: 10th International Conference on Frontotemporal Dementias
  • Place of Presentation: Munich, Germany
  • Year and Date: 2016-08-31
  • Int'l Joint Research
• [Presentation] Lifetime prevalence, psychiatric comorbidity and demographic correlates of “hikikomori” in a community population in Japan. (2016)
  • Author(s): Koyama A.
  • Organizer: 31st International Congress of Psychology
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2016-07-24
  • Int'l Joint Research
• [Presentation] 中高年の地域住民における食習慣と抑うつとの関連について (2016)
  • Author(s): 西良知, 小山明日香, 福永竜太, 阿部恭久, 向坂香織, 藤瀬 昇, 池田学.
  • Organizer: 第35回日本社会精神医学会
  • Place of Presentation: 岡山
  • Year and Date: 2016-01-28
• [Presentation] Mental Health among Dementia Caregivers: Comparison with Community Residents (2015)
  • Author(s): Asuka Koyama, Masateru Matsushita, Mamoru Hashimoto, Noboru Fujise, Tomohisa, Ishikawa, Yoshitomo Nishi, Manabu Ikeda.
  • Organizer: The 9th International Congress of the Asian Society Against Dementia
  • Place of Presentation: Kumamoto, Japan
  • Year and Date: 2015-09-14
  • Int'l Joint Research
• [Presentation] Living alone is associated with depression among male elderly in a rural community in Japan. (2015)
  • Author(s): Noboru Fujise, Asuka Koyama, Yasuhisa Abe, Yoshitomo Nishi, Ryuta Fukunaga, Manabu Ikeda.
  • Organizer: World Psychiatric Association (WPA) Regional congress Osaka Japan 2015
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2015-06-04
  • Int'l Joint Research
• [Presentation] Epidemiological studies on mental health among the elderly. (2015)
  • Author(s): Asuka Koyama, Noboru Fujise, Manabu Ikeda.
  • Organizer: World Psychiatric Association (WPA) Regional congress Osaka Japan 2015
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2015-06-04
  • Int'l Joint Research
• [Presentation] International comparison study of caregiver burden for Alzheimer’s disease in Japan and Taiwan: results from Dementia Research in Kumamoto and Tainan (2015)
  • Author(s): Matsushita M, Pai MC, Jhou CY, Koyama A, Ikeda M.
  • Organizer: Taiwanese Society of Geriatric Psychiatry 9th annual meeting
  • Place of Presentation: Taiwan
  • Year and Date: 2015-03-14 – 2015-03-15
  • Invited
• [Presentation] Withdrawal and its related factors among the community-dwelling elderly (2014)
  • Author(s): Koyama A, Abe Y, Fukunaga R, Nishi Y, Matsushita M, Fujise N, Ikeda
  • Organizer: WPA Section on Epidemiology and Public Health - 2014 Meeting.
  • Place of Presentation: Nara
  • Year and Date: 2014-10-16 – 2014-10-18
• [Presentation] 認知症患者における希死念慮を伴う抑うつの出現の特徴. (2014)
  • Author(s): 小山明日香, 藤瀬昇, 松下正輝, 石川智久, 西良知, 橋本衛, 池田学.
  • Organizer: 第38回日本自殺予防学会総会
  • Place of Presentation: 北九州
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] 熊本県におけるうつ病の医療連携についての取り組み. (2014)
  • Author(s): 西良知, 小山明日香, 宮本憲司朗, 福永竜太, 阿部恭久, 内村太, 藤瀬昇, 池田学.
  • Organizer: 第11回日本うつ病学会総会
  • Place of Presentation: 広島
  • Year and Date: 2014-07-18 – 2014-07-19
• [Presentation] 一般高齢住民における口腔内違和感と抑うつについての関連についての検討 (2014)
  • Author(s): 深川淳至, 平田真一, 福永竜太, 阿部恭久, 西良知, 小山明日香, 藤瀬昇, 池田学.
  • Organizer: 第110回日本精神神経学会
  • Place of Presentation: 横浜
  • Year and Date: 2014-06-26 – 2014-06-28
• [Presentation] 認知症の介護負担感とSense of Coherenｃeの関係. (2014)
  • Author(s): 松下正輝, 石川智久, 小山明日香, 長谷川典子, 一美奈緒子, 池田学.
  • Organizer: 第29回日本老年精神医学会
  • Place of Presentation: 東京
  • Year and Date: 2014-06-12 – 2014-06-13
• [Book] 認知症とストレス．『ストレス学ハンドブック』 (2015)
  • Author(s): 小山明日香, 池田学
  • Total Pages: 548
  • Publisher: 創元社