Development of ion conductance microscopy with high spatio-temporal resolution for visualizing nanostructures of bio samples in liquid environment
| Project/Area Number |
26790048
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Thin film/Surface and interfacial physical properties
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| Research Institution | Kanazawa University |
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Principal Investigator |
Watanabe Shinji 金沢大学, バイオAFM先端研究センター, 助教 (70455864)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 物理計測・制御 / 走査プローブ顕微鏡 / ナノバイオ / メゾスコピック系 |
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| Outline of Final Research Achievements |
We have succeeded in capturing topographic images of samples located in liquid environments from over 10 um scale down to the sub-10 nm scale within a few seconds.
Clearly resolved images of biological samples with sub-10-nm vertical and lateral structures demonstrate the capability of scanning ion conductance microscopy for imaging actions in biological systems with high spatial resolution.
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| Academic Significance and Societal Importance of the Research Achievements |
ナノピペットを用いる走査型プローブ顕微鏡、走査型イオン伝導顕微鏡の高速化に取り組み、従来の100倍程度高速でイメージングできる装置を開発した。これを用いて、いくつかのバイオ試料のイメージングを行った。本装置は、生細胞などのダメージに弱いバイオ試料の形状のイメージングやその動態を計測するのに有用であると考えられる。
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Report
(4 results)
Research Products
(19 results)
