Construction of amylose hybrid polymer library for next-generation chaperone system.
Project/Area Number |
26810113
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Polymer/Textile materials
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Research Institution | Kyoto University |
Principal Investigator |
Nishimura Tomoki 京都大学, 工学(系)研究科(研究院), 研究員 (60648070)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | アミロース / 酵素重合 / シャペロン / 両親媒性ポリマー / 糖鎖 |
Outline of Final Research Achievements |
We prepared a library of amphiphilic amylose-based star copolymers using a copper catalyzed click reaction. We then evaluated chaperon function of a series of these molecules for heat denatured carbonic anhydrate and optimized chemical structure for chaperon functioning polymer. We also synthesized a novel light-sensitive nanogel using cholesterol modified with an ortho-nitrobenzyl unit on the hydroxyl group of pullulan. The use of light-sensitive components makes it possible to create patterned nanogel films that can immobilize proteins. The preparation of patterned materials is important for the construction of micro- or nanodevices such as MEMS and biomolecular chips.
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Report
(3 results)
Research Products
(14 results)