Pathogenic roles of actin metabolism in cerebral small vessel disease
Project/Area Number |
26830039
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Nerve anatomy/Neuropathology
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Research Institution | National Cardiovascular Center Research Institute |
Principal Investigator |
Yamamoto Yumi 国立研究開発法人国立循環器病研究センター, 研究所, 流動研究員 (10614927)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | CADASIL / 脳小血管病 / 脳梗塞 / CADASIL / 遺伝性脳小血管病 / 血管性認知症 |
Outline of Final Research Achievements |
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary cerebral small vessel disease caused by the mutations in NOTCH3 gene expressed in mural cells. Although many studies have conducted, the exact pathogenesis remains unclear. Here, we generated induced pluripotent stem cells (iPSCs) from CADASIL patients and differentiated them into mural cells (MCs) to replicate the pathology in vitro. Comparison between control and CADASIL MCs revealed altered migration and adhesion ability of CADASIL MCs. Those results suggests that actin metabolism is deeply involved in the pathogenesis of CADASIL.
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Report
(3 results)
Research Products
(2 results)
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[Presentation] PATIENT-DERIVED IPS CELLS FOR UNRAVELING THE MOLECULAR PATHOGENESIS OF CADASIL2015
Author(s)
Yumi Yamamoto, Katsutoshi Kojima, Daisuke Taura, Masakatsu Sone, Kazuo Washida, Naohiro Egawa, Takayuki Kondo, Eiko N Minakawa, Kayoko Tsukita, Takako Enami, Hidekazu Tomimoto, Toshiki Mizuno, Ryosuke Takahashi, Masafumi Ihara, Haruhisa Inoue
Organizer
VASCOG world
Place of Presentation
東京ファッションタウン
Year and Date
2015-09-16
Related Report
Int'l Joint Research