| Project/Area Number |
26830039
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
Yamamoto Yumi 国立研究開発法人国立循環器病研究センター, 研究所, 流動研究員 (10614927)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ＣＡＤＡＳＩＬ / 脳小血管病 / 脳梗塞 / CADASIL / 遺伝性脳小血管病 / 血管性認知症 |
|---|
| Outline of Final Research Achievements |
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary cerebral small vessel disease caused by the mutations in NOTCH3 gene expressed in mural cells. Although many studies have conducted, the exact pathogenesis remains unclear. Here, we generated induced pluripotent stem cells (iPSCs) from CADASIL patients and differentiated them into mural cells (MCs) to replicate the pathology in vitro. Comparison between control and CADASIL MCs revealed altered migration and adhesion ability of CADASIL MCs. Those results suggests that actin metabolism is deeply involved in the pathogenesis of CADASIL.
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