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Integrative understanding of epigenetic silencing in neuropathic pain

Research Project

Project/Area Number 26830048
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurochemistry/Neuropharmacology
Research InstitutionNiigata University

Principal Investigator

Uchida Hitoshi  新潟大学, 脳研究所, 助教 (30549621)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords神経障害性疼痛 / エピジェネティクス / NRSF / 脊髄後根神経節 / 遺伝子発現 / 転写共役因子
Outline of Final Research Achievements

We have previously provided evidence that epigenetic gene silencing via neuron restrictive silencer factor (NRSF) is important in nerve injury-induced neuropathic pain. The present study revealed that injury induced the expressions of co-factors of NRSF and histone modifying enzymes in the primary afferents. Also, we showed that histone deacetylase inhibitors ameliorated morphine resistance in neuropathic pain via cancellation of the epigenetic silencing of mu opioid receptor gene.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (5 results)

  • [Journal Article] Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury2015

    • Author(s)
      Uchida H, Matsushita Y, Araki K, Mukae T,Ueda H
    • Journal Title

      J Pharmacol Sci

      Volume: 128(4) Issue: 4 Pages: 208-211

    • DOI

      10.1016/j.jphs.2015.07.040

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epigenetic modification in neuropathic pain2015

    • Author(s)
      Hiroshi Ueda and Hitoshi Uchida
    • Journal Title

      Current Pharmaceutical Design

      Volume: 21 Issue: 7 Pages: 849-867

    • DOI

      10.2174/1381612820666141027113923

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lysophosphatidic acid and its receptors LPA1 and LPA3 mediate paclitaxel-induced neuropathic pain in mice.2014

    • Author(s)
      Uchida H, Nagai J, Ueda H
    • Journal Title

      Mol Pain

      Volume: 10:71 Pages: 1-7

    • DOI

      10.1186/1744-8069-10-71

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 神経障害性疼痛誘発因子リゾホスファチジン酸によるミエリン関連遺伝子の転写抑制機構2015

    • Author(s)
      内田仁司、植田弘師
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-03-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 慢性疼痛とエピジェネティクス2015

    • Author(s)
      内田仁司、植田弘師
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-03-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 断続的冷温負荷による線維筋痛症モデルに対するドネペジルの疼痛改善作用2014

    • Author(s)
      内田仁司、迎武紘、植田弘師
    • Organizer
      第67回日本薬理学会西南部会
    • Place of Presentation
      北九州市
    • Year and Date
      2014-11-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 創薬に向けた線維筋痛症モデル動物の病態解析と治療戦略2014

    • Author(s)
      内田仁司、植田弘師
    • Organizer
      日本線維筋痛症学会第6回学術集会
    • Place of Presentation
      長野市
    • Year and Date
      2014-09-14
    • Related Report
      2014 Research-status Report
  • [Presentation] 神経障害性疼痛原因分子LPAによる脱髄とアセチル化修飾2014

    • Author(s)
      内田仁司、濱田将徳、植田弘師
    • Organizer
      第36回日本疼痛学会
    • Place of Presentation
      大阪市
    • Year and Date
      2014-06-21
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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