Integrative understanding of epigenetic silencing in neuropathic pain
Project/Area Number |
26830048
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Neurochemistry/Neuropharmacology
|
Research Institution | Niigata University |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 神経障害性疼痛 / エピジェネティクス / NRSF / 脊髄後根神経節 / 遺伝子発現 / 転写共役因子 |
Outline of Final Research Achievements |
We have previously provided evidence that epigenetic gene silencing via neuron restrictive silencer factor (NRSF) is important in nerve injury-induced neuropathic pain. The present study revealed that injury induced the expressions of co-factors of NRSF and histone modifying enzymes in the primary afferents. Also, we showed that histone deacetylase inhibitors ameliorated morphine resistance in neuropathic pain via cancellation of the epigenetic silencing of mu opioid receptor gene.
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Report
(3 results)
Research Products
(8 results)