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Molecular mechanisms governing glia-neuron interaction in the sensory system

Research Project

Project/Area Number 26830049
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurochemistry/Neuropharmacology
Research InstitutionOsaka City University

Principal Investigator

KAGE-NAKADAI Eriko  大阪市立大学, 大学院生活科学研究科, 准教授 (40453790)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywordsグリア細胞 / 線虫 / 浸透圧 / 感覚器 / グリア / コンディショナルノックアウト
Outline of Final Research Achievements

Glial cells control many aspects of the nervous system, including the regulation of survival, differentiation and interconnection of neurons, in both vertebrates and invertebrates. The Caenorhabditis elegans (C. elegans) amphid sensory organ is a simple model for analyzing glia or neuron-glia interactions. To better characterize glial development and function, we carried out RNA interference screening for transcription factors that regulate the expression of an amphid sheath glial cell marker and identified pros-1, which encodes a homeodomain transcription factor homologous to Drosophila prospero/mammalian Prox1, as a positive regulator. We demonstrated that the C. elegans PROS-1 is a transcriptional regulator in the glia but is involved not only in sensory behavior but also in sensory-mediated physiological tolerance.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (24 results)

All 2018 2017 2016 2015 2014

All Journal Article (13 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 13 results,  Open Access: 10 results,  Acknowledgement Compliant: 3 results) Presentation (11 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results)

  • [Journal Article] Sesamin extends lifespan through pathways related to dietary restriction in Caenorhabditis elegans2018

    • Author(s)
      Nakatani, Y., Yaguchi, Y., Komura, T., Nakadai, M., Terao, K., Kage-Nakadai, E., and Nishikawa, Y.
    • Journal Title

      Eur. J. Nut.

      Volume: 57 Issue: 3 Pages: 1137-1146

    • DOI

      10.1007/s00394-017-1396-0

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Influence of lactic acid and post-treatment recovery time on the heat resistance of Listeria monocytogenes2017

    • Author(s)
      Omori Y, Miake K, Nakamura H, Kage-Nakadai E, Nishikawa Y.
    • Journal Title

      Int J Food Microbiol.

      Volume: 257 Pages: 10-18

    • DOI

      10.1016/j.ijfoodmicro.2017.06.008

    • NAID

      120006319606

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2019909

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence of Diarrheagenic <i>Escherichia coli</i> in Foods and Fecal Specimens Obtained from Cattle, Pigs, Chickens, Asymptomatic Carriers, and Patients in Osaka and Hyogo, Japan2017

    • Author(s)
      95.Wang, L., Zhang, S., Zheng, D., Fujihara, S., Wakabayashi, A., Okahata, K., Suzuki, M., Saeki, A., Nakamura, H., Hara-Kudo, Y., Kage-Nakadai, E., and Nishikawa, Y.
    • Journal Title

      Japanese Journal of Infectious Diseases

      Volume: 70 Issue: 4 Pages: 464-469

    • DOI

      10.7883/yoken.JJID.2016.486

    • NAID

      130005851923

    • ISSN
      1344-6304, 1884-2836
    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2019930

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prevalence, antimicrobial resistance and multiple-locus variable-number tandem-repeat analysis profiles of diarrheagenic Escherichia coli isolated from different retail foods2017

    • Author(s)
      Wang Lili、Nakamura Hiromi、Kage-Nakadai Eriko、Hara-Kudo Yukiko、Nishikawa Yoshikazu
    • Journal Title

      Int. J. Food Microbiol.

      Volume: 249 Pages: 44-52

    • DOI

      10.1016/j.ijfoodmicro.2017.03.003

    • NAID

      120006485147

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2019908

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Caenorhabditis elegans homolog of Prox1/Prospero is expressed in the glia and is required for sensory behavior and cold tolerance.2016

    • Author(s)
      Kage-Nakadai E., Ohta, A., Ujisawa T., Sun S., Nishikawa Y., Kuhara A., Mitani S.
    • Journal Title

      Genes to Cells

      Volume: 21(9) Issue: 9 Pages: 936-948

    • DOI

      10.1111/gtc.12394

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Distinct roles of the two VPS33 proteins in the endolysosomal system in Caenorhabditis elegans2016

    • Author(s)
      Gengyo-Ando K, Kage-Nakadai E, Yoshina S, Otori M, Kagawa-Nagamura Y, Nakai J, Mitani S
    • Journal Title

      Traffic

      Volume: 17 Issue: 11 Pages: 1197-1213

    • DOI

      10.1111/tra.12430

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Curcumin improves tau-induced neuronal dysfunction of nematodes.2016

    • Author(s)
      Miyasaka, T., Xie, C., Yoshimura, S., Shinzaki, Y., Yoshina, S., Kage-Nakadai, E., Mitani, S., Ihara, Y.
    • Journal Title

      Neurobiol. Aging

      Volume: 39 Pages: 69-81

    • DOI

      10.1016/j.neurobiolaging.2015.11.004

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Locus-specific integration of extrachromosomal transgenes in C. elegans with the CRISPR/Cas9 system2016

    • Author(s)
      Yoshina et al.
    • Journal Title

      BBRep

      Volume: 5 Pages: 70-76

    • DOI

      10.1016/j.bbrep.2015.11.017

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of unstable pEntYN10 from enterotoxigenic Escherichia coli (ETEC) O169:H412015

    • Author(s)
      102.Ban, E., Yoshida, Y., Wakushima, M., Wajima, T., Hamabata, T., Ichikawa, N., Abe, H., Horiguchi, Y., Hara-Kudo, Y., Kage-Nakadai, E., Yamamoto, T., Wada, T., and Nishikawa, Y.
    • Journal Title

      Virulence

      Volume: 6 Issue: 8 Pages: 735-744

    • DOI

      10.1080/21505594.2015.1094606

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Tumor Suppressor BCL7B Functions in the Wnt Signaling Pathway.2015

    • Author(s)
      Uehara T, Kage-Nakadai E, Yoshina S, Imae R, Mitani S.
    • Journal Title

      PLoS Genet.

      Volume: 11 Issue: 1 Pages: e1004921-e1004921

    • DOI

      10.1371/journal.pgen.1004921

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Conditional Knockout Toolkit for Caenorhabditis elegans Based on the Cre/loxP Recombination.2014

    • Author(s)
      Kage-Nakadai E, Imae R, Suehiro Y, Yoshina S, Hori S, Mitani S.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 12 Pages: e114680-e114680

    • DOI

      10.1371/journal.pone.0114680

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Methods for single/low-copy integration by ultraviolet and trimethylpsoralen treatment in Caenorhabditis elegans.2014

    • Author(s)
      Kage-Nakadai E, Imae R, Yoshina S, Mitani S
    • Journal Title

      Methods

      Volume: Mar 12 Issue: 3 Pages: 91-7

    • DOI

      10.1016/j.ymeth.2014.02.036

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of oral supplementation with sesamin on longevity of Caenorhabditis elegans and the host defense2014

    • Author(s)
      Yaguchi, Y., Komura, T., Kashima, N., Tamura, M., Kage-Nakadai, E., Saeki, S., Terao, K., Nishikawa, Y.
    • Journal Title

      Eur. J. Nut.

      Volume: 53 Issue: 8 Pages: 1659-1668

    • DOI

      10.1007/s00394-014-0671-6

    • NAID

      120006576122

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2019838

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Influence of Propionibacterium acnes on host defense of Caenorhabditis elegans,2017

    • Author(s)
      Yumi Hamazaki, Satomi Kamimura, Satoshi Inada, Simo Sun, Tomomi Komura, Shuta Tomida, Yoshikazu Nishikawa, Eriko Kage-Nakadai
    • Organizer
      The 16th Awaji International Forum on Infection and Immunity
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diffusely adherent Escherichia coli (DAEC) strains isolated from healthy carriers inhibit IL-8 secretion of epithelial cells by the type VI secretion system (T6SS)2017

    • Author(s)
      Narumi Takeuchi, Yoshihiko Tanimoto, Sayaka Tamai, Saki Yanagida, Yoshihiro Yamaguchi, Eriko Kage-Nakadai, Yoshikazu Nishikawa
    • Organizer
      The 16th Awaji International Forum on Infection and Immunity
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Adhesion of human enterotoxigenic Escherichia coli (ETEC) O169:H41 to porcine intestinal epithelial cells by the novel colonization factor2017

    • Author(s)
      Omori, Y., Zheng, D., Ban, E., Kage-Nakadai, E., Tachibana, T., Wada, T., Hara-Kudo, Y., and Nishikawa, Y
    • Organizer
      Vaccines for Enteric Diseases
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 線虫C.elegansを用いた食品に含まれる苦味物質に対する応答のメカニズム解明2017

    • Author(s)
      飯田千晴、西川禎一、中台(鹿毛)枝里子
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 線虫におけるビフィズス菌(Bifidobacterium infantis)への低嗜好性に関わるニューロンおよび分子メカニズム2017

    • Author(s)
      孫 思墨、西川 禎一、中台 枝里子
    • Organizer
      第56回日本栄養・食糧学会近畿支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 線虫 C.elegans を用いた食品中の苦味物質に対する生体応答の解析2017

    • Author(s)
      飯田千晴、孫思墨、西川禎一、中台(鹿毛)枝里子
    • Organizer
      第56回日本栄養・食糧学会近畿支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Host responses to probiotic bacteria in C. elegans.2016

    • Author(s)
      Kage-Nakadai, E., Nishikawa, Y.
    • Organizer
      第89回日本細菌学会学術総会
    • Place of Presentation
      大阪国際センター(大阪府、大阪市)
    • Year and Date
      2016-03-24
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] A Caenorhabditis elegans homolog of Prox1/Prospero functions in the glia and is required for the development of sensory neurons.2015

    • Author(s)
      Kage-Nakadai, E., Sun, S., Nishikawa, Y., Mitani,
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫県、神戸市)
    • Year and Date
      2015-07-30
    • Related Report
      2015 Research-status Report
  • [Presentation] A conditional knockout system using single/low-copy transgene integration and deletion mutant strains in Caenorhabditis elegans.2015

    • Author(s)
      E. Kage-Nakadai
    • Organizer
      2015 Japan-Korea International Academic Symposium
    • Place of Presentation
      大阪市立大学(大阪府、大阪市)
    • Year and Date
      2015-03-18 – 2015-03-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Approaches to sensory processing mechanisms using Caenorhabditis elegans models.2015

    • Author(s)
      E. Kage-Nakadai
    • Organizer
      The 2014 OCARINA Annual International Meeting
    • Place of Presentation
      大阪市立大学(大阪府、大阪市)
    • Year and Date
      2015-03-04 – 2015-03-05
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] A conditional knockout system based on the combination of UV/TMP single-copy integration methods and deletion mutant strains in C. elegans.2014

    • Author(s)
      E. Kage-Nakadai, R. Imae, O. Funatsu, S. Hori, Y. Suehiro, S. Yoshina, and S. Mitani
    • Organizer
      6th Asia-Pacific C. elegans Meeting
    • Place of Presentation
      奈良新公会堂(奈良県、奈良市)
    • Year and Date
      2014-07-14 – 2014-07-17
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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