FROM THE QUESTION OF HOW GLIAL CELLS WRAP THEIR MEMBRANE WITH AXONS TO THE POSSIBLE SOLUTION OF HOW DEMYELINATING DISORDERS WERE RECOVERED
| Project/Area Number |
26830054
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | National Center for Child Health and Development |
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Principal Investigator |
Miyamoto Yuki 国立研究開発法人国立成育医療研究センター, 薬剤治療研究部, 研究員 (50425708)
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| Research Collaborator |
KAWAHARA Kazuko 国立成育医療研究センター
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 髄鞘 / グリア細胞 / 神経細胞 / 共培養 / オリゴデンドロサイト / ミエリン / 細胞間相互作用 |
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| Outline of Final Research Achievements |
During postnatal development in the central nervous system (CNS), oligodendrocytes differentiate to wrap their plasma membranes around neuronal axons, forming the myelin sheath. Although a neuronal cue is one of the regulator elements controlling this process, the overall picture remains elusive. Our experiments using microarray analysis in primary oligodendrocytes have revealed that vascular cell adhesion molecule (VCAM) 1, which plays a key role throughout the immune system, is one of their transcripts. VCAM1 contributes to the initiation of myelination through ligand ligation , demonstrating that an intercellular molecule whose primary role is in the immune system can also play an unexpected role in the CNS.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Social isolation impairs remyelination in mice through modulation of IL-6.2016
Author(s)
Makinodan M, Ikawa D, Miyamoto Y, Yamauchi J, Yamamuro K, Yamashita Y, Toritsuka M, Kimoto S, Okumura K, Yamauchi T, Fukami SI, Yoshino H, Wanaka A, Kishimoto T.
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Journal Title
FASEB J.
Volume: 30
Issue: 12
Pages: 4267-4274
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Involvement of the Tyro3 receptor and its intracellular partner Fyn signaling in Schwann cell myelination.2015
Author(s)
Yuki Miyamoto, Tomohiro Torii, Shuji Takada, Nobuhiko Ohno, Yurika Saitoh, Kazuaki Nakamura, Akihito Ito, Toru Ogata, Nobuo Terada, Akito Tanoue, and Junji Yamauchi
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Journal Title
Mol. Biol. Cell
Volume: 26
Issue: 19
Pages: 3489-3503
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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