| Project/Area Number |
26830063
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory animal science
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| Research Institution | National Institutes of Biomedical Innovation, Health and Nutrition |
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Principal Investigator |
Uchio Kozue 国立研究開発法人医薬基盤・健康・栄養研究所, 疾患モデル小動物研究室, 主任研究員 (70373397)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 疾患モデル / 腎疾患 / 実験動物 |
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| Outline of Final Research Achievements |
The number of patients with kidney diseases is expected to increase steadily each year in Japan. It has not been reported the effective therapy for renal insufficiency. Since the mechanisms responsible for kidney diseases have not been completely made clear yet, it is difficult to discover effective drugs. One of the reasons for the difficulties is that suitable animal models for various kidney diseases don’t exist. Usually, C57BL/6 mice are used in order to develop models by genetic engineering, but C57BL/6 is resistant to kidney diseases. Therefore, it is difficult to establish mouse models for kidney diseases on C57BL/6 background. In this study, I identified susceptible loci of kidney diseases and established C57BL/6 strains carrying the loci. These strains might contribute to elucidate the mechanisms responsible for kidney diseases and to develop effective therapy.
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