The new aspects of carcinoembryonic antigen as the tumor marker
Project/Area Number |
26830100
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Tumor diagnostics
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Research Institution | Keio University (2015-2016) Shizuoka Cancer Center Research Institute (2014) |
Principal Investigator |
Nakao Kanako 慶應義塾大学, 医学部(信濃町), 特任助教 (30583059)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | CEA / 腫瘍マーカー / アイソフォーム / スプライスバリアント / 膵臓がん / 癌 / 膵臓 / 膵疾患 |
Outline of Final Research Achievements |
Carcinoembryonic antigen (CEA) is an oncofetal cell surface glycoprotein overexpressed in human gastrointestinal tumors. Because of its high expression in tumors and secretion to serum, CEA has been widely used as a serum tumor marker. However, the secretion of CEA in cancer tissues is not well defined. We previously identified two novel CEA protein isoforms in gastrointestinal cancer cell lines. CEA isoforms were also secreted to culture medium. Although CEA isoforms always co-existed with the wild type of CEA, the secretion patterns of these isoforms were different from the expression patterns. In this study, we established the stable cell lines expressing each CEAs and examined the isoforms-specific antibodies. Furthermore, we also determined the expression/secretion manner of the CEAs in pancreatic cancer cell lines.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] A novel splice variant of XIAP-associated factor 1 (XAF1) is expressed in peripheral blood containing gastric cancer-derived circulating tumor cells2015
Author(s)
Hatakeyama, K., Yamakawa, Y., Fukuda, Y., Ohshima, K., Wakabayashi-Nakao, K., Sakura, N., Tanizawa, Y., Kinugasa, Y., Yamaguchi, K., Terashima, M., Mochizuki, T
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Journal Title
Gastric Cancer
Volume: 18
Issue: 4
Pages: 751-761
DOI
Related Report
Peer Reviewed
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[Journal Article] A novel splice variant of XIAP-associated factor 1 (XAF1) is expressed in peripheral blood containing gastric cancer-derived circulating tumor cells.2014
Author(s)
Hatakeyama, K.; Yamakawa, Y.; Fukuda, Y.; Ohshima, K.; Wakabayashi-Nakao, K.; Sakura, N.; Tanizawa, Y.; Kinugasa, Y.; Yamaguchi, K.; Terashima, M.; Mochizuki, T.
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Journal Title
Gastric cancer
Volume: 印刷中
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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