| Project/Area Number |
26830111
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
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| Research Institution | Yokohama City University |
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Principal Investigator |
Kobayashi Nobuaki 横浜市立大学, 附属市民総合医療センター, 講師 (60468155)
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| Research Collaborator |
SHIBATA Yuji 横浜市立大学, 大学院医学研究科・呼吸器病学教室, 非常勤診療医
SHINKAI Masaharu 横浜市立大学, 大学院医学研究科・呼吸器病学教室, 准教授
KUDO Makoto 横浜市立大学, 附属市民総合医療センター・呼吸器病センター, 准教授
KANEKO Takeshi 横浜市立大学, 大学院医学研究科・呼吸器病学教室, 教授
SHIROTA Hidekazu 東北大学, 大学院医学研究科・腫瘍内科学教室, 講師
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | poly G ODN / 合成オリゴヌクレオチド / 抗癌免疫療法 / M1マクロファージ / 樹状細胞 / 抗腫瘍免疫 / 免疫療法 / 腫瘍免疫 / 抗腫瘍免疫活性 / poly-G ODN |
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| Outline of Final Research Achievements |
Synthetic oligonucleotides (ODN) containing specific sequences have an immunomodulatory effect. We previously reported that a novel poly-G ODN has an anti-tumor immune effect in a tumor-bearing murine model. Here, we identified poly-G ODN-induced T cell proliferation and production of interferon-gamma through the enhancement of monocyte maturation in human mononuclear cells isolated from the peripheral blood or from the malignant pleural effusion of lung cancer patients. Poly-G ODN also induces the maturation of human monocytes into M1 macrophages through the phosphorylation of STAT1. This mechanism of poly-G ODN in humans is unique from that reported previously in mice for some ODNs containing three guanosines at the 3' tail. Further studies are ongoing to establish a novel anti-cancer immunotherapy for lung cancer with poly-G ODN.
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