transcriptional regulatory elements of a novel atrial specific gene

Research Project

Project/Area Number	26830133
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Medical genome science
Research Institution	Keio University
Principal Investigator	OHGINO YASUYUKI 慶應義塾大学, 医学部(信濃町), 助教 (20598916)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	心房特異的遺伝子 / 転写調節 / 心房 / 乳幼児突然死 / 遺伝子
Outline of Final Research Achievements	To find a novel atrial specific gene, we conducted comparable gene array analysis between neonatal rat atrial and ventricular cardiomyocytes. To conduct gene array analysis, we purified cardiomyocytes. Then, we successfully discovered an new atrial specific gene. To identify the transcriptional regulatory elements of the gene, we conducted a reporter gene assay and find an one of the transcriptional regions. In addition, we investigated the function of the gene by using KO mice.

Report

(4 results)