Comprehensive screening of novel host proteins cleaved by HCV protease

• Project/Area Number: 26830140
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: System genome science
• Research Institution: Kanagawa Cancer Center Research Institute
• Principal Investigator: Muroi Atsushi 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 研究員 (60609402)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: C型肝炎ウイルス / プロテアーゼ / 宿主因子 / ウイルス / 無細胞タンパク質合成

Outline of Final Research Achievements

Comprehensive screening of novel host proteins cleaved by HCV protease
HCV is known as a causative virus of hepatitis C. Approximately 180 million people are infected by the virus worldwide partially leading to hepatic cirrhosis and carcinoma. In this study, I attempted to comprehensively screen host proteins, which were potential target molecules for HCV treatment, cleaved by HCV protease. Novel host proteins, which affected HCV amplification in cells, were identified by the screening.