| Project/Area Number |
26840070
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 核膜構造 / 老化 / 代謝 / メタボローム / ミトコンドリア / 核構造 / ラミンA / プロジェリア / メタボローム解析 / ミトコンドリア代謝 / 代謝酵素 |
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| Outline of Final Research Achievements |
Although the stability of nuclear membrane is correlated with the cellular aging process, the molecular mechanism is still unknown. In this study, the relationship between cellular metabolism and the nuclear membrane abnormality was investigated. When expressed in cell, the progerin protein, the dominant negative mutant of lamin A, did not influence a major energy-generating metabolism including glycolysis and TCA cycle. Rather, the the protein increased the quantity of N-formylmethionine, which resides in mitochondria and play roles in translation process. These results raise the possibility of previously undescribed crosstalk between nuclear stability and mitochondrial physiology.
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