| Project/Area Number |
26840072
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
kimura kenji 国立遺伝学研究所, 構造遺伝学研究センター, 助教 (40644505)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 核配置 / 細胞質流動 / キネシン / 線虫 / 多核細胞 / 核 / 受精卵 |
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| Outline of Final Research Achievements |
In this study, I analyzed the dynamics of the nucleus in the fertilized embryo and in the multinucleated intestinal cell of C. elegans to reveal a diverse mechanisms of the nuclear positioning in the cell. Previously, a motor protein dynein has been known as a major regulator of the nuclear positioning. I found that (1) the sperm-derived nucleus utilizes cytoplasmic streaming that emerges after fertilization to position itself in the proper location in the embryo, and (2) a motor protein kinesin-1 is involved in the nuclear positioning in the intestinal cell. This study will reveal new mechanisms of the nuclear positioning in various cell types.
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