| Project/Area Number |
26840082
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Kumamoto University |
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Principal Investigator |
Tanaka Tsubasa 熊本大学, 発生医学研究所, 助教 (00392027)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 生殖細胞 / エンドサイトーシス / 卵黄タンパク / 細胞極性 / RNA局在 / 小胞輸送 |
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| Outline of Final Research Achievements |
Germ cells ensure the continuity of life through the generation. In many species, germ cells are determined by the inheritance of the germ plasm, which contains mRNAs and proteins that specify germ cell fate and promote germline development. We have previously shown that, in Drosophila, local activation of endocytosis at the posterior end of the oocyte is critical for the assembly of germ plasm. In this study, we focused on the function of yolk protein receptor Yolkless in the germ plasm assembly and found that the endocytic vesicles generated by yolk protein uptake act as platforms for the establishment of oocyte polarity and the germ plasm assembly. As yolk positions in eggs often provide a polarity cue, this model might be adaptive to the polarity mechanism of eggs in various species.
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