| Project/Area Number |
26840084
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
Yano Tohru 東京慈恵会医科大学, 医学部, 助教 (10648091)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 糖鎖 / 発生 / 四肢 / 鰭 / 骨格 / ゼブラフィッシュ / 組織分化 / 進化 / マウス / 形態形成 |
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| Outline of Final Research Achievements |
In vertebrates, fins and limbs are thought to be homologous appendages. In fish , however, the fin-specific epithelial structure (apical fold) develops and lepidotrichia (intramembranous bones) are formed within the apical fold region.
In order to understand mechanisms of fish-specific structures, we demonstrated molecular and developmental analyses of the pectoral fin development in zebrafish (Danio rerio), and found that ext (exostosin) genes, which were ubiquitously expressed in development, were important for the formation of the apical fold. Especially, we showed that extl3 gene in zebrafish played an important role not in regulation of limb-developmental pathways mediated by HSPG, but simply in architectural ECM components.
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