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Analysis of Ecl1 family proteins that extends chronological lifespan

Research Project

Project/Area Number 26850048
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied microbiology
Research InstitutionNagoya University

Principal Investigator

Ohtsuka Hokuto  名古屋大学, 創薬科学研究科, 助教 (10632151)

Research Collaborator Tenno Takeshi  
Shimasaki Takafumi  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsEcl1 family遺伝子 / ecl1 / 経時寿命 / 亜鉛 / 分裂酵母 / 鉄 / 性分化 / 有性生殖 / Ecl1 familyタンパク質 / Ecl1 / Ecl1 family / 寿命
Outline of Final Research Achievements

We identified that fission yeast Schizosaccharomyces pombe responses to the environmental levels of zinc or iron and causes the sexual development or the chronological lifespan extension. We also showed that these responses require Ecl1 family genes. We reported these as following papers.
(1)Ohtsuka H, et al. Mol Genet Genomics. 2015 (2)Shimasaki T, Ohtsuka H, et al. Mol Genet Genomics. 2017

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2017 2015 2014

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (8 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Ecl1 is a zinc binding protein that is involved in the zinc-limitation dependent extension of chronological lifespan in fission yeast.2017

    • Author(s)
      Takafumi Shimasaki, Hokuto Ohtsuka, Chikako Naito, Takeshi Tenno, Hidekazu Hiroaki, Hiroshi Murakami, Hirofumi Aiba
    • Journal Title

      Molecular Genetics and Genomics

      Volume: 292 Issue: 2 Pages: 475-481

    • DOI

      10.1007/s00438-016-1285-x

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sexual development of Schizosaccharomyces pombe is induced by zinc or iron limitation through Ecl1 family genes.2015

    • Author(s)
      Ohtsuka H, Ishida M, Naito C, Murakami H, Aiba H.
    • Journal Title

      Mol Genet Genomics.

      Volume: 290 Issue: 1 Pages: 173-185

    • DOI

      10.1007/s00438-014-0911-8

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A new pma1 mutation identified in a chronologically long-lived fission yeast mutant.2014

    • Author(s)
      Naito C, Ito H, Oshiro T, Ohtsuka H, Murakami H, Aiba H.
    • Journal Title

      FEBS Open Bio.

      Volume: 4 Issue: 1 Pages: 829-833

    • DOI

      10.1016/j.fob.2014.09.006

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of wee1(+) expression during meiosis in fission yeast.2014

    • Author(s)
      Murakami-Tonami Y, Ohtsuka H, Aiba H, Murakami H.
    • Journal Title

      Cell Cycle.

      Volume: 13 Issue: 18 Pages: 2853-2858

    • DOI

      10.4161/15384101.2014.946807

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ecl1 is activated by the transcription factor Atf1 in response to H2O2 stress in Schizosaccharomyces pombe.2014

    • Author(s)
      Shimasaki T, Ohtsuka H, Naito C, Murakami H, Aiba H.
    • Journal Title

      Mol Genet Genomics.

      Volume: 289 Issue: 4 Pages: 685-693

    • DOI

      10.1007/s00438-014-0845-1

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 分裂酵母における経時寿命延長因子Ecl1ファミリータンパク質の機能解析2015

    • Author(s)
      島崎嵩史、大塚北斗、内藤知佳子、村上浩士、饗場浩文
    • Organizer
      第38回 日本分子生物学会年会 第88回 日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] Functional analysis of Ecl1 family proteins that extend chronological lifespan of Schizosaccharomyces pombe.2015

    • Author(s)
      T. Shimasaki, H. Ohtsuka, M. Ishida, C. Naito, H. Aiba
    • Organizer
      The eighth international fission yeast meeting.
    • Place of Presentation
      神戸
    • Year and Date
      2015-06-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sexual development of S. pombe is induced by iron or zinc limitation.2015

    • Author(s)
      M. Ishida, H. Ohtsuka, H. Murakami, H. Aiba.
    • Organizer
      The eighth international fission yeast meeting.
    • Place of Presentation
      神戸
    • Year and Date
      2015-06-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 新規な性分化シグナル・亜鉛枯渇におけるEcl1ファミリー遺伝子の機能解析2014

    • Author(s)
      石田麻衣子、大塚北斗、村上浩士、饗場浩文
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 分裂酵母における経時寿命延長因子 Ecl1ファミリータンパク質の解析2014

    • Author(s)
      島崎嵩史、大塚北斗、石田麻衣子、内藤知佳子、饗場浩文
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 分裂酵母における経時寿命延長因子 Ecl1ファミリータンパク質の解析2014

    • Author(s)
      島崎嵩史、大塚北斗、石田麻衣子、内藤知佳子、饗場浩文
    • Organizer
      日本農芸化学会中部支部第171回例会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2014-10-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 分裂酵母における経時寿命延長因子Ecl1ファミリータンパク質の解析2014

    • Author(s)
      大塚北斗、島崎嵩史、石田麻衣子、内藤知佳子、饗場浩文
    • Organizer
      酵母遺伝学フォーラム第47回研究報告会
    • Place of Presentation
      東京大学
    • Year and Date
      2014-09-01 – 2014-09-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 新規な性分化シグナル・亜鉛枯渇におけるEcl1ファミリー遺伝子の機能解析2014

    • Author(s)
      石田麻衣子、大塚北斗、村上浩士、饗場浩文
    • Organizer
      酵母遺伝学フォーラム第47回研究報告会
    • Place of Presentation
      東京大学
    • Year and Date
      2014-09-01 – 2014-09-03
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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