Elucidation of molecular mechanisms involved in the expression of function of rice-derived bioactive proteins by X-ray crystallographic analysis
| Project/Area Number |
26850077
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Niigata University |
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Principal Investigator |
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| Research Collaborator |
SUGAI Hiroshi 新潟大学, 自然科学研究科, 大学院生
WATANABE Kazuhito 新潟大学, 自然科学研究科, 大学院生
KANAOKA Takumi 新潟大学, 自然科学研究科, 大学院生
OHORI Masahiro 新潟大学, 自然科学研究科, 大学院生
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | α-アミラーゼ / ディフェンシン / イネ / 生理活性タンパク質 / 免疫亢進 / 生理活性 |
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| Outline of Final Research Achievements |
In previous research, we found an α-amylase and defensin-like proteins from rice proteins as bioactive proteins involved in activating biophylactic function in human. In this research project, in order to propose these bioactive proteins as novel medicines that may enhance immune function, we further explored the biophylactic function of these proteins in humans. Furthermore, we analyzed structural factors involved in expression of their functions by analyzing their three-dimensional structures and intermolecular interaction between the proteins and their target molecules.
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Report
(4 results)
Research Products
(10 results)
