The inhibitory mechanism of viral replication by lactophorin that functions in infected cells.
| Project/Area Number |
26850078
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Food science
|
|---|
| Research Institution | Gifu University |
|---|
Principal Investigator |
INAGAKI Mizuho 岐阜大学, 応用生物科学部, 助教 (50626356)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | ラクトフォリン / ヒトロタウイルス / 感染防御 / 糖鎖 / 牛乳 / レクチン / ロタウイルス |
|---|
| Outline of Final Research Achievements |
Rotavirus is the leading cause of severe gastroenteritis in infants. 18 kDa Lactophorin (LP) , which contains in bovine skim milk, suppresses the synthesis and assembly of viral protein by interaction with the host cells. It suggests that LP inhibits the early stages of viral infection, namely adhesion, penetration, uncoating. This activity might be attributed O-link glycans in LP.
|
Report
(3 results)
Research Products
(8 results)
