Elucidation of inflammatory mechanism and pathologic role in iron dysregulation in chronic liver diseases.
| Project/Area Number |
26850184
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
Izawa Takeshi 大阪府立大学, 生命環境科学研究科(系), 准教授 (20580369)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 慢性肝疾患 / 鉄代謝 / 肝硬変 / 代謝性疾患 / 炎症 / 鉄過剰 / マクロファージ / 線維化 / 鉄代謝障害 |
|---|
| Outline of Final Research Achievements |
Iron overload is considered as a risk factor for chronic liver diseases; however, the mechanism is still unclear. In this study, we showed that imbalance between macrophages and inflammatory cytokines is related to development of iron overload in the advanced stage of chronic liver disease in rats. We also showed that dietary iron overload suppresses liver injury in rats with chemically-induced liver cirrhosis whereas it enhances liver inflammation in rats with metabolic liver disease. These findings can be useful basic data for understanding the complex mechanism of progression of chronic liver diseases.
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Report
(3 results)
Research Products
(12 results)
