| Project/Area Number |
26850188
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Nihon University |
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Principal Investigator |
SATO Shingo 日本大学, 生物資源科学部, 助手 (60708593)
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| Research Collaborator |
MARUYAMA Soichi
KABEYA Hidenori
SUZUKI Kazuo
TAMATE Hidetoshi
YAMAZAKI Shouki
CHOMEL Bruno B.
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | Bartonella quintana / ニホンザル / 塹壕熱 / MLST / 赤血球 |
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| Outline of Final Research Achievements |
Bartonella quintana is known as the causative agent of trench fever. The disease caused major epidemics among soldiers in World Wars I and II. Humans are thought to be the unique natural reservoir for B. quintana, but this bacterium has also been isolated from captive-bred cynomolgus amd rhesus macaques in other countries. However, no epidemiological studies of B. quintana have been conducted in wild macaques.
The aim of the present study was to investigate the prevalence of B. quintana in wild Japanese macaques. In addition, we evaluated the potential pathogenicity of monkey-derived B. quintana for humans.
Bartonella quintana was isolated from six (13.3%) of 45 wild-caught Japanese macaques. The genetic characteristics of the isolates were found to be different from other known B. quintana strains derived from humans and captive-bred macaques. Moreover, it was suggested that the Japanese macaque strain has the potential to infect and invade into the human erythrocytes.
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