Characterization of canine novel mesenchymal stem cells adhering to adipocytes in bone marrow for clinical application in regenerative therapy.
| Project/Area Number |
26850192
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Veterinary medical science
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
Fujita Naoki 東京大学, 大学院農学生命科学研究科(農学部), 特任助教 (10554488)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 間葉系幹細胞 / 犬 / 骨髄 / 再生医療 / 犬骨髄間葉系幹細胞 / 肝細胞成長因子 / 骨髄脂肪 / 幹細胞治療 / 骨髄間葉系幹細胞 / 脂肪細胞 / 肝細胞成長因子（HGF） |
|---|
| Outline of Final Research Achievements |
We developed novel mesenchymal stem cells from canine bone marrow and named the cells as bone marrow per-adipocyte cells（BM-PACs). BM-PACs attached to adipocytes in bone marrow and have superior potentials as multipotent cells compared with conventional canine bone marrow mesenchymal stem cells (BMMSCs). Additionally, BM-PACs showed higher expression of hepatocyte growth factor (HGF), which is known to have great healing effects on injured tissues, than BMMSCs. After locally injected into a mouse skin injury model, BM-PACs migrated toward the injured area and showed HGF expression. In addition, intravenously injected BM-PACs also migrated toward injured area and showed HGF expression. Thus, our results suggest that stem cell therapy using BM-PACs offer a healing effect through the supply of HGF to the injured site.
|
Report
(4 results)
Research Products
(7 results)
