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Establishment of novel morphological atlas of mouse embryonic development focusing on the extraembryonic environment

Research Project

Project/Area Number 26850210
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Integrative animal science
Research InstitutionResearch Institute, Osaka Medical Center for Maternal and Child Health (2015-2016)
National Institute of Infectious Diseases (2014)

Principal Investigator

Hiramatsu Ryuji  地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), 病因病態部門, 客員研究員 (70555284)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords胚発生 / マウス / 体軸形成 / 着床 / 細胞外基質
Outline of Final Research Achievements

In mammal, embryogenesis progresses in uterus of mother. Therefore, the understanding of the relationship between embryo and uterine tissue is required to revealing the detail process of early mouse embryonic development. I have investigated the relationship between mouse embryo and uterine tissue beyond implantation stage by performing histological and expression analysis. I have obtained the basic data to establish novel morphological atlas of early mouse embryo and maternal uterine tissue. Especially, I performed the detail observation of the dynamic morphological change of mouse embryo and uterine tissues at implantation stage (4.5 dpc). This observation revealed the process how the mouse embryo was incorporated in the uterine tissue.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2017 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Mechanical perspectives on the anterior-posterior axis polarization of mouse implanted embryos2017

    • Author(s)
      Matsuo I., and Hiramatsu R.
    • Journal Title

      Mech Dev.

      Volume: 144(Pt A) Pages: 62-70

    • DOI

      10.1016/j.mod.2016.09.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Mechanical interaction among embryonic, extraembryonic and maternal tissues for the anterior-posterior axis formation in mouse embryo2015

    • Author(s)
      Ryuji Hiramatsu, Isao Matsuo
    • Organizer
      EMBO Workshop: Embryonic-Extraembryonic Interfaces
    • Place of Presentation
      Goettingen, Germany
    • Year and Date
      2015-05-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Mechanical interaction between embryo and maternal uterine tissue in the anterior-posterior axis formation of mouse embryo2014

    • Author(s)
      Ryuji Hiramatsu, Chiharu Kimura-Yoshida, Isao Matsuo
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 胚発生過程における“力”をどのように捉えるか2014

    • Author(s)
      平松竜司
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 着床期の哺乳類胚発生における胚‐母体間の力学的相互作用2014

    • Author(s)
      平松竜司
    • Organizer
      第54回先天異常学会学術集会
    • Place of Presentation
      麻布大学(神奈川県相模原市)
    • Year and Date
      2014-07-26 – 2014-07-27
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2018-03-22  

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