• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Dissecting the function and regulation of mitochondrial quality control system using multi-matrixed screening assay

Research Project

Project/Area Number 26860063
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pharmacology in pharmacy
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Toshimori Kitami  国立研究開発法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (70708594)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsミトコンドリア / スクリーニング / 炎症
Outline of Final Research Achievements

Decline in mitochondrial function is associated with variety of complex diseases including type 2 diabetes, neurodegenerative disease, and cardiovascular disease. Mitochondrial function is maintained at the level of abundance and quality. We sought to study the role of mitochondrial quality control in complex disease pathway called NLRP3 inflammasome. This pathway triggers the release of inflammatory cytokine and is involved in variety of complex diseases. We performed focused genetic over-expression and knockout screens to assess the impact of mitochondrial quality control genes on inflammatory phenotype. In addition, we performed genome-wide knockout screens for NLRP3 inflammasome activation to assess which mitochondrial genes are involved in this disease pathway. The results of the study will help clarify the role of mitochondria in inflammation as well as identify novel genes involved in regulating NLRP3 inflammasome.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results)

  • [Presentation] Dissecting the role of mitochondria in NLRP3 inflammasome activation via chemical and genomic toolkits2015

    • Author(s)
      北見 俊守
    • Organizer
      第15回 日本ミトコンドリア学会年会
    • Place of Presentation
      福井県国際交流会館(福井県福井市宝永)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi