Investigation of rice component inducing the production of malbrancheoside A from Malbranchea filamentosa

• Project/Area Number: 26860070
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Natural medicines
• Research Institution: Hoshi University
• Principal Investigator: WAKANA Daigo 星薬科大学, 薬学部, 助教 (80700129)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 米 / トリテルペン / 産生制御 / Malbranchea / Malbranchea filamentosa / 新規化合物 / トリテルペン産生誘導 / 真菌 / 二次代謝産物産生能

Outline of Final Research Achievements

To identify the rice component inducing the production of malbrancheosides from Malbranchea filamentosa, the production of malbracheosides guided fractionation of rice broth was performed. As the results, γ-oryzanol including fraction showed the production of malbracheoside A.
In the course of this experiments, new diterpene type meroterpenoid glycoside and furanone glycoside were isolated.