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Attempt to develop a prevention against environmental stress-related hearing loss.

Research Project

Project/Area Number 26860089
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Environmental and hygienic pharmacy
Research InstitutionJapan Organization of Occupational Health and Safety Japan Bioassay Research Center (2017)
Chubu University (2014-2016)

Principal Investigator

Goto Yuko  独立行政法人労働者健康安全機構 日本バイオアッセイ研究センター(試験管理部、病理検査部), その他部局等, 研究員 (80722090)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords環境ストレス / 難聴 / 内耳 / ラセン神経節 / 環境因子 / 騒音 / 農薬
Outline of Final Research Achievements

This study analyzed hearing loss in mice caused by environmental stresses including noise and pesticides in order to clarify a role of molecule E, which has been shown to express in auditory neurons. Neonicotinoide (NN-pesticide) is known to one of the pesticides to suppress the function of nAChR in insects. nAChR has been shown to express in inner ears in mammals and to be regulated by Sox10 which is one of the E-related molecules. Thus, it is possible that the NN-pesticide affects hearing. However, there is no study showing the correlation between NN-pesticide and hearing levels in mice. We exposed mice to acetamiprid which is one of the NN-pesticides via drinking water for 4 weeks. Auditory brainstem response showed a tendency to be decrease of hearing in exposed group. Furthermore, we tried qPCR to determine expression levels of molecule E in inner ears from mice exposed to environmental stresses such as NN-pesticide. However, the expression of molecule E was not able to evaluated.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2016 2014

All Presentation (2 results)

  • [Presentation] 小型哺乳類の聴覚に対するネオニコチノイド系農薬の影響.2016

    • Author(s)
      後藤裕子
    • Organizer
      第63回日本生態学会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-03-20
    • Related Report
      2015 Research-status Report
  • [Presentation] ネオニコチノイド系農薬の耳毒性の検討2014

    • Author(s)
      後藤裕子
    • Organizer
      第32回農薬環境科学研究会
    • Place of Presentation
      ホテルアンビア松風閣(静岡県焼津市)
    • Year and Date
      2014-11-20 – 2014-11-21
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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