The maximam effect and the velocity of antihypertensive effects of drugs for hypertension determined by home blood pressuremeasurements

• Project/Area Number: 26860093
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Tohoku University
• Principal Investigator: Satoh Michihiro 東北大学, 大学病院, 特別研究員(PD) (70717892)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 降圧薬 / 薬効評価 / 高血圧 / アンジオテンシンⅡ受容体拮抗薬

Outline of Final Research Achievements

We aimed to examine the blood pressure (BP)-lowering effect and the time to attain the maximal antihypertensive effect (stabilization time) of several angiotensin II receptor blockers (ARBs) based on home BP measurements. We surveyed consecutive newly diagnosed, untreated patients with hypertension who started the treatment with a mid-level dose of one of seven ARBs. All study participants measured home BP in the morning for at least 1 week during an untreated period and 4 weeks during the treatment period (total n=232; age, 62.2 years; 50.9% men; home SBP/DBP, 151.6/90.0 mmHg). The maximum effect / the stabilization time based on home systolic BP were 15.3 mmHg/ 7.1 days for azilsartan 20 mg, 14.7 mmHg/ 9.2 days for olmesartan 20 mg, 13.7 mmHg/ 8.9 days for telmisartan 40 mg, 12.9 mmHg/ 11.0 days for candesartan 8 mg, 11.9 mmHg/ 22.8 days for losartan 50 mg, 8.2 mmHg/ 4.7 days for irbesartan 100 mg, and 7.9 mmHg/ 7.1 days for valsartan 80 mg.

Research Products

• [Journal Article] The velocity of antihypertensive effects of seven angiotensin II receptor blockers determined by home blood pressure measurements. (2016)
  • Author(s): Satoh M, Haga T, Hosaka M, Obara T, Metoki H, Murakami T, Kikuya M, Inoue R, Asayama K, Mano N, Ohkubo T, Imai Y.
  • Journal Title: Journal of Hypertension Volume: - Issue: 6 Pages: 1218-1223
  • DOI: 10.1097/hjh.0000000000000902
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Does Antihypertensive Drug Class Affect Day-to-Day Variability of Self-Measured Home Blood Pressure? The HOMED-BP Study. (2016)
  • Author(s): Asayama K, Ohkubo T, Hanazawa T, Watabe D, Hosaka M, Satoh M, Yasui D, Staessen JA, Imai Y, Hypertensive Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure Study Investigators.
  • Journal Title: Journal of the American Heart Association Volume: 5 Issue: 3
  • DOI: 10.1161/jaha.115.002995
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Home blood pressure level and decline in renal function among treated hypertensive patients: the J-HOME-Morning Study. (2016)
  • Author(s): Ishikura K, Obara T, Kikuya M, Satoh M, Hosaka M, Metoki H, Nishigori H, Mano N, Nakayama M, Imai Y, Ohkubo T.
  • Journal Title: Hypertens Res Volume: 39(2) Issue: 2 Pages: 107-112
  • DOI: 10.1038/hr.2015.110
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 家庭血圧に基づくアジルサルタンの臨床的評価 (2015)
  • Author(s): 芳賀俊和, 佐藤倫広, 保坂実樹, 渡部大介, 小原拓, 目時弘仁, 浅山敬, 菊谷昌浩, 眞野成康, 大久保孝義, 今井潤.
  • Organizer: 第38回日本高血圧学会総会
  • Place of Presentation: 愛媛県県民文化会館（愛媛県、松山市）
  • Year and Date: 2015-10-10
• [Presentation] 家庭血圧に基づくアジルサルタンの降圧度・降圧速度評価 (2015)
  • Author(s): 芳賀俊和、保坂実樹、渡部大介、今井潤、佐藤倫広、眞野成康、小原拓、菊谷昌浩、目時弘仁、浅山敬、大久保孝義.
  • Organizer: 第17回時間循環血圧研究会
  • Place of Presentation: 東京コンフアレンスセンター・品川（東京都、港区）
  • Year and Date: 2015-07-04
• [Presentation] 家庭血圧に基づくアンジオテンシンⅡ受容体拮抗薬7種の降圧速度・最大降圧効果の評価 (2015)
  • Author(s): 佐藤倫広, 芳賀俊和, 保坂実樹, 渡部大介, 小原拓, 目時弘仁, 浅山敬, 菊谷昌浩, 眞野成康, 大久保孝義, 今井潤.
  • Organizer: 第11回実地臨床高血圧研究会
  • Place of Presentation: リーガロイヤルホテル小倉（福岡県、北九州市）
  • Year and Date: 2015-06-27
• [Presentation] 電子血圧計を用いた客観的な高血圧治療に関する研究（HOMED-BP研究）参加主治医に関する質問表調査 (2015)
  • Author(s): 安井大策, 浅山敬, 佐藤倫広, 保坂実樹, 花澤智大, 渡部大介, 大久保孝義, 今井潤, HOMED-BP研究グループ.
  • Organizer: 第4回臨床高血圧フォーラム
  • Place of Presentation: アクロス福岡（福岡県、福岡市）
  • Year and Date: 2015-05-23
• [Presentation] 本態性高血圧患者における家庭血圧と脳心血管疾患発症リスクの男女別解析：HOMED-BP研究 (2014)
  • Author(s): 保坂実樹, 浅山敬, 佐藤倫広, 井上隆輔, 小原拓, 目時弘仁, 菊谷昌浩, 大久保孝義, 今井潤.
  • Organizer: 第37回日本高血圧学会総会
  • Place of Presentation: パシフィコ横浜 (神奈川県、横浜市)
  • Year and Date: 2014-10-17