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The maximam effect and the velocity of antihypertensive effects of drugs for hypertension determined by home blood pressuremeasurements

Research Project

Project/Area Number 26860093
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionTohoku University

Principal Investigator

Satoh Michihiro  東北大学, 大学病院, 特別研究員(PD) (70717892)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords降圧薬 / 薬効評価 / 高血圧 / アンジオテンシンⅡ受容体拮抗薬
Outline of Final Research Achievements

We aimed to examine the blood pressure (BP)-lowering effect and the time to attain the maximal antihypertensive effect (stabilization time) of several angiotensin II receptor blockers (ARBs) based on home BP measurements. We surveyed consecutive newly diagnosed, untreated patients with hypertension who started the treatment with a mid-level dose of one of seven ARBs. All study participants measured home BP in the morning for at least 1 week during an untreated period and 4 weeks during the treatment period (total n=232; age, 62.2 years; 50.9% men; home SBP/DBP, 151.6/90.0 mmHg). The maximum effect / the stabilization time based on home systolic BP were 15.3 mmHg/ 7.1 days for azilsartan 20 mg, 14.7 mmHg/ 9.2 days for olmesartan 20 mg, 13.7 mmHg/ 8.9 days for telmisartan 40 mg, 12.9 mmHg/ 11.0 days for candesartan 8 mg, 11.9 mmHg/ 22.8 days for losartan 50 mg, 8.2 mmHg/ 4.7 days for irbesartan 100 mg, and 7.9 mmHg/ 7.1 days for valsartan 80 mg.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 3 results,  Open Access: 1 results) Presentation (5 results)

  • [Journal Article] The velocity of antihypertensive effects of seven angiotensin II receptor blockers determined by home blood pressure measurements2016

    • Author(s)
      Satoh M, Haga T, Hosaka M, Obara T, Metoki H, Murakami T, Kikuya M, Inoue R, Asayama K, Mano N, Ohkubo T, Imai Y.
    • Journal Title

      Journal of Hypertension

      Volume: 34 Issue: 6 Pages: 1218

    • DOI

      10.1097/hjh.0000000000000902

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Does antihypertensive drug class affect day-to-day variability of self-measured home blood pressure? The HOMED-BP study2016

    • Author(s)
      Asayama K, Ohkubo T, Hanazawa T, Watabe D, Hosaka M, Satoh M, Yasui D, Staessen JA, Imai Y, Hypertensive Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure Study Investigators.
    • Journal Title

      Journal of the American Heart Association

      Volume: 5 Issue: 3

    • DOI

      10.1161/jaha.115.002995

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Home blood pressure level and decline in renal function among treated hypertensive patients: The J-HOME-Morning Study2016

    • Author(s)
      Ishikura K, Obara T, Kikuya M, Satoh M, Hosaka M, Metoki H, Nishigori H, Mano N, Nakayama M, Imai Y, Ohkubo T.
    • Journal Title

      Hypertens Res

      Volume: 39 Issue: 2 Pages: 107

    • DOI

      10.1038/hr.2015.110

    • URL

      https://pure.teikyo.jp/en/publications/d043a878-a564-4c83-b864-5e6be2b87348

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 家庭血圧に基づくアジルサルタンの臨床的評価2015

    • Author(s)
      芳賀俊和, 佐藤倫広, 保坂実樹, 渡部大介, 小原拓, 目時弘仁, 浅山敬, 菊谷昌浩, 眞野成康, 大久保孝義, 今井潤.
    • Organizer
      第38回日本高血圧学会総会
    • Place of Presentation
      愛媛県県民文化会館(愛媛県、松山市)
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 家庭血圧に基づくアジルサルタンの降圧度・降圧速度評価2015

    • Author(s)
      芳賀俊和、保坂実樹、渡部大介、今井潤、佐藤倫広、眞野成康、小原拓、菊谷昌浩、目時弘仁、浅山敬、大久保孝義.
    • Organizer
      第17回時間循環血圧研究会
    • Place of Presentation
      東京コンフアレンスセンター・品川(東京都、港区)
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 家庭血圧に基づくアンジオテンシンⅡ受容体拮抗薬7種の降圧速度・最大降圧効果の評価2015

    • Author(s)
      佐藤倫広, 芳賀俊和, 保坂実樹, 渡部大介, 小原拓, 目時弘仁, 浅山敬, 菊谷昌浩, 眞野成康, 大久保孝義, 今井潤.
    • Organizer
      第11回実地臨床高血圧研究会
    • Place of Presentation
      リーガロイヤルホテル小倉(福岡県、北九州市)
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 電子血圧計を用いた客観的な高血圧治療に関する研究(HOMED-BP研究)参加主治医に関する質問表調査2015

    • Author(s)
      安井大策, 浅山敬, 佐藤倫広, 保坂実樹, 花澤智大, 渡部大介, 大久保孝義, 今井潤, HOMED-BP研究グループ.
    • Organizer
      第4回臨床高血圧フォーラム
    • Place of Presentation
      アクロス福岡(福岡県、福岡市)
    • Year and Date
      2015-05-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 本態性高血圧患者における家庭血圧と脳心血管疾患発症リスクの男女別解析:HOMED-BP研究2014

    • Author(s)
      保坂実樹, 浅山敬, 佐藤倫広, 井上隆輔, 小原拓, 目時弘仁, 菊谷昌浩, 大久保孝義, 今井潤.
    • Organizer
      第37回日本高血圧学会総会
    • Place of Presentation
      パシフィコ横浜 (神奈川県、横浜市)
    • Year and Date
      2014-10-17
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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