• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A study of pathology and therapy of the dementia associated with testosterone supplementation-refractory late onset hypogonadism syndrome

Research Project

Project/Area Number 26860135
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General anatomy (including histology/embryology)
Research InstitutionUniversity of Occupational and Environmental Health, Japan (2015)
Yamaguchi University (2014)

Principal Investigator

KOKUBU Keiji  産業医科大学, 医学部, 助教 (00432740)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords男性更年期障害 / 芳香化酵素 / アンドロゲン / エストロゲン / エストロゲン受容体 / 扁桃体 / テストステロン / アロマテース / 性ステロイドホルモン
Outline of Final Research Achievements

Aromatase which create estrogen from testosterone and two types of estrogen receptor (ERα and ERβ) are expressed in the medial amygdaloid nucleus of the brain. Therefore, it is expected that the brains of men is influenced by estrogen than the women brain.
In the medial amygdaloid nucleus of the castrated male rats used as a model of the male menopause, the quantity of ERα protein was increased in comparison with sham-operated rats. The administration of testosterone or estrogen to the castrated rat decreased ERα protein again. In contrast, the administration of the dihydrotestosterone which was a kind of androgen did not affect the quantity of ERα.
The quantity of the ER β protein was stable without being affected by castration and any sex steroidal hormones.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2015

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Species differences in androgen receptor expression in the medial preoptic and anterior hypothalamic areas of adult male and female rodents.2015

    • Author(s)
      Jahan MR, Kokubu K, Islam MN, Matsuo C, Yanai A, Wroblewski G, Fujinaga R, Shinoda K.
    • Journal Title

      Neuroscience

      Volume: 284 Pages: 943-961

    • DOI

      10.1016/j.neuroscience.2014.11.003

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi