Physiological function of D1 dopamine receptor-expressing astrocyte of substantia nigra
| Project/Area Number |
26860143
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | D1ドーパミン受容体 / アストロサイト / ドーパミン受容体 / 黒質網様部 |
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| Outline of Final Research Achievements |
Substantia nigra pars reticulata (SNr) receives dopamine (DA) from dendrites (dendritic release) extending into this nucleus from dopaminergic neurons in the adjacent nucleus pars compacta, which is known to be selectively degenerated in Parkinson’s disease. Recently, we found acutely dissociated adult SNr astrocytes showed anti-D1 dopamine receptor (D1R) antibody immunoreactivity which might be as a recipient for dendritically released DA. Present study, the physiological function of D1R expressed in SNr astrocytes was examined by electrophysiological study in mouse brain slice and behavior analysis of SNr astrocyte-specific D1R-conditional knockout (D1R-CKO) mouse. The electrophysiological approach have yet given clues for the physiological function. A trouble on establishment of D1R-CKO mouse happened in the delivery process, then this approach could not be performed. The work for anti-D1R antibody immunoreactivity of acutely dissociated adult astrocyte was published on Feb., 2017.
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] Auto-oxidation products of epigallo-catechin gallate activate TRPA1 and TRPV1 in sensory neurons.2015
Author(s)
Kurogi, M., Kawai, Y., Nagatomo, K., Tateyama, M., Kubo, Y. and Saitoh, O.
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Journal Title
Chemical Senses
Volume: 40(1)
Issue: 1
Pages: 27-46
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum.2014
Author(s)
Miyazaki H, Oyama F, Inoue R, Aosaki T, Abe T, Kiyonari H, Kino Y, Kurosawa M, Shimizu J, Ogiwara I, Yamakawa K, Koshimizu Y, Fujiyama F, Kaneko T, Shimizu H, Nagatomo K, Yamada K, Shimogori T, Hattori N, Miura M, Nukina N.
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Journal Title
Nat Commun.
Volume: 5
Issue: 1
Pages: 5525-5525
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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