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Central circuit mechanisms underlying infection-induced symptoms

Research Project

Project/Area Number 26860159
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionNagoya University (2015-2017)
Kyoto University (2014)

Principal Investigator

Nakamura Yoshiko  名古屋大学, 医学系研究科, 助教 (60548543)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords発熱 / 摂食 / 代謝 / プロスタグランジン / 視床下部 / 体温調節 / 感染
Outline of Final Research Achievements

Infection elicits a variety of central symptoms, such as fever, decreased appetite, and fatigue. However, the neural mechanisms underlying the infection-induced symptoms are unknown. In this study, I focused on preoptic area neurons that express prostaglandin EP3 receptors, which receive the pyrogenic mediator produced in response to infections. By using a technique to express reporter genes specifically in EP3 receptor-expressing neurons in the preoptic area, I revealed all the brain sites to which EP3 receptor-expressing preoptic neurons project their axons, and also electrophysiologically recorded activities of these neurons. Based on the data obtained from these analyses, I hypothesized that the medullary reticular neurons are involved in the infection-induced suppression of appetite. Further studies to test this hypothesis could lead to elucidation of the central neural circuit mechanisms of infection-induced symptoms.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (27 results)

All 2018 2017 2016 2015 2014 Other

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (19 results) (of which Int'l Joint Research: 6 results,  Invited: 4 results) Remarks (4 results)

  • [Journal Article] The lateral parabrachial nucleus, but not the thalamus, mediates thermosensory pathways for behavioural thermoregulation.2017

    • Author(s)
      Takaki Yahiro, Naoya Kataoka, Yoshiko Nakamura & Kazuhiro Nakamura
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 5031-5041

    • DOI

      10.1038/s41598-017-05327-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Central regulation of brown adipose tissue thermogenesis and energy homeostasis dependent on food availability.2017

    • Author(s)
      Yoshiko Nakamura & Kazuhiro Nakamura
    • Journal Title

      Pfulgers Arch. - Eur. J. Physiol.

      Volume: 印刷中 Issue: 5 Pages: 823-837

    • DOI

      10.1007/s00424-017-2090-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 飢餓反応の中枢神経回路メカニズム.2017

    • Author(s)
      中村和弘、中村佳子
    • Journal Title

      肥満研究

      Volume: 23 Pages: 161-168

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Medullary Reticular Neurons Mediate Neuropeptide Y-Induced Metabolic Inhibition and Mastication.2017

    • Author(s)
      Nakamura Y, Yanagawa Y, Morrison SF, Nakamura K.
    • Journal Title

      Cell Metab.

      Volume: 25 Issue: 2 Pages: 322-334

    • DOI

      10.1016/j.cmet.2016.12.002

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 温度知覚と体温調節行動は異なる温度感覚伝達路で駆動される2018

    • Author(s)
      中村和弘、八尋貴樹、片岡直也、中村佳子
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] "Hypothalamic neuropeptide Y inhibits brown adipose tissue thermogenesis via activation of medullary reticular GABAergic neurons "2017

    • Author(s)
      Yoshiko Nakamura, Yuchio Yanagawa, Shaun F. Morrison, Kazuhiro Nakamura
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 外側腕傍核を介した脳への環境温度情報伝達は体温調節行動を駆動する2017

    • Author(s)
      八尋貴樹、片岡直也、中村佳子、中村和弘
    • Organizer
      第12回環境生理学プレコングレス
    • Place of Presentation
      サーラシティ浜松(静岡県浜松市)
    • Year and Date
      2017-03-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 飢餓を生き延びるための脳の神経回路メカニズム2017

    • Author(s)
      中村佳子、中村和弘
    • Organizer
      科研費新学術領域「温度生物学」 領域会議
    • Place of Presentation
      生理学研究所(愛知県岡崎市)
    • Year and Date
      2017-01-19
    • Related Report
      2016 Research-status Report
  • [Presentation] ニューロペプチドYによる熱産生抑制と摂食亢進の神経メカニズム2017

    • Author(s)
      中村佳子、中村和弘
    • Organizer
      生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Medullary reticular nuclei control metabolism and food intake during starvation2017

    • Author(s)
      Yoshiko Nakamura, Yuchio Yanagawa, Shaun F. Morrison, Kazuhiro Nakamura
    • Organizer
      国際自律神経学会(ISAN)2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Medullary reticular GABAergic neurons that mediate hunger responses induced by hypothalamic neuropeptide Y2017

    • Author(s)
      Yoshiko Nakamura, Yuchio Yanagawa, Shaun F. Morrison, Kazuhiro Nakamura
    • Organizer
      EB2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Determination of thermosensory pathways required for behavioural thermoregulation2017

    • Author(s)
      Takaki Yahiro, Naoya Kataoka, Yoshiko Nakamura and Kazuhiro Nakamura
    • Organizer
      EB2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lateral parabrachial nucleus mediates thermosensory signaling for behavioral thermoregulation2017

    • Author(s)
      Takaki Yahiro, Naoya Kataoka, Yoshiko Nakamura, Kazuhiro Nakamura
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 外側腕傍核を介した神経伝達が駆動する体温調節行動2017

    • Author(s)
      八尋貴樹, 片岡直也, 中村佳子, 中村和弘
    • Organizer
      温熱生理研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 行動性体温調節を駆動する外側腕傍核を介した温度感覚上行路の探索2017

    • Author(s)
      八尋貴樹, 片岡直也, 中村佳子, 中村和弘
    • Organizer
      自律神経研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Medullary neural circuit for neuropeptide Y-mediated inhibition of brown adipose tissue thermogenesis2016

    • Author(s)
      Yoshiko Nakamura, Yuchio Yanagawa, Shaun F. Morrison, Kazuhiro Nakamura
    • Organizer
      6th International Conference on the Physiology and Pharmacology of Temperature Regulation (PPTR2016)
    • Place of Presentation
      Ljubljana (Slovenia)
    • Year and Date
      2016-12-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ニューロペプチドYは延髄網様体GABAニューロンを介して熱産生抑制を行なう2016

    • Author(s)
      中村佳子,柳川右千夫,Shaun F. Morrison, 中村和弘
    • Organizer
      平成28年度 温熱生理研究会
    • Place of Presentation
      生理学研究所(愛知県岡崎市)
    • Year and Date
      2016-08-29
    • Related Report
      2016 Research-status Report
  • [Presentation] Neural circuit mechanism for hypothalamic neuropeptide Y-induced inhibition of brown adipose tissue thermogenesis2016

    • Author(s)
      Yoshiko Nakamura, Yuchio Yanagawa, Shaun F. Morrison, Kazuhiro Nakamura
    • Organizer
      Experimental Biology 2016 (米国生理学会)
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2016-04-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] "ニューロペプチドYによる代謝抑制を担う神経回路:飢餓を生き延びるための仕組み"2016

    • Author(s)
      中村佳子、中村和弘
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 視床下部ニューロペプチドYによる褐色脂肪熱産生の抑制メカニズム2016

    • Author(s)
      中村佳子、柳川右千夫、Shaun F. Morrison、中村和弘
    • Organizer
      環境生理プレコングレス
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2016-03-21
    • Related Report
      2015 Research-status Report
  • [Presentation] Medullary reticular GABAergic neurons mediate neuropeptide Y-induced inhibition of brown adipose tissue thermogenesis2015

    • Author(s)
      Yoshiko Nakamura, Yuchio Yanagawa, Shaun F. Morrison and Kazuhiro Nakamura
    • Organizer
      The international society for autonomic neuroscience (ISAN) 2015
    • Place of Presentation
      Stresa Convention Centre, Stresa, (Italy)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neuropeptide Yが褐色脂肪熱産生を抑制する中枢神経回路メカニズム2015

    • Author(s)
      中村佳子,柳川右千夫,Shaun F. Morrison, 中村和弘
    • Organizer
      平成27年度温熱生理研究会
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県岡崎市)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Research-status Report
  • [Presentation] Neuropeptide Y signaling from the hypothalamus inhibits sympathetic outflow to brown adipose tissue through GABA inhibition of the rostral medullary raphe2014

    • Author(s)
      Yoshiko Nakamura and Kazuhiro Nakamura
    • Organizer
      Experimental Biology 2014
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      2014-04-26 – 2014-04-30
    • Related Report
      2014 Research-status Report
  • [Remarks] 名古屋大学医学系研究科統合生理学分野

    • URL

      https://www.med.nagoya-u.ac.jp/physiol2/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 名古屋大学大学院医学系研究科統合生理学

    • URL

      http://www.med.nagoya-u-ac.jp/physiol2

    • Related Report
      2016 Research-status Report
  • [Remarks] 名古屋大学医学系研究科統合生理学

    • URL

      http://www.med.nagoya-u.ac.jp/physiol2/

    • Related Report
      2015 Research-status Report
  • [Remarks] 京都大学生命科学系キャリアパス形成ユニット中村グループ

    • URL

      http://www.cp.kyoto-u.ac.jp/Nakamura/nakamura-j.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

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