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Identifying new nociceptor in skeletal muscle and its involvement in hyperalgesia

Research Project

Project/Area Number 26860161
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionTeikyo University

Principal Investigator

OTA Hiroki  帝京大学, 医療技術学部, 助教 (10712432)

Research Collaborator TAGUCHI Toru  富山大学, 大学院医学薬学研究部, 客員准教授
MIZUMURA Kazue  中部大学, 生命健康科学部, 教授
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords痛み / 骨格筋 / 遅発性筋痛 / 末梢神経系 / 機械痛覚過敏 / 侵害受容器 / 筋・筋膜性疼痛
Outline of Final Research Achievements

The“silent nociceptor” is defined as a receptor that does not respond to mechanical stimulation in normal condition but responds to it in pathological condition. However, its existence has not been demonstrated in fibers innervating skeletal muscle. Here in this study we recorded C-fiber activities by in vivo single fiber recording technique, and investigated their axonal properties, their responses to noxious stimulation, and acquisition of the responsibility after injection of sensitizing substances. As a result, 7 of 58 mechanically insensitive C-fibers were presumed to be “silent nociceptors”, the proportion of which was different from other tissues. Among mechanically insensitive C-fibers, one of them got mechanical sensitivity after injecting a mixture of sensitizing substances (bradykinin, serotonin, prostaglandin E2, and histamine).

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 Other

All Journal Article (1 results) Presentation (4 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] 骨格筋新規侵害受容器の活性化機構の解明2016

    • Author(s)
      太田大樹
    • Journal Title

      公益財団法人中冨健康科学振興財団研究助成業績集

      Volume: 27

    • Related Report
      2016 Annual Research Report
  • [Presentation] 遅発性筋痛におけるプロスタグランジン受容体の関与2016

    • Author(s)
      太田大樹
    • Organizer
      第3回筋性疼痛研究会
    • Place of Presentation
      名古屋大学東山キャンパス(愛知県名古屋市)
    • Year and Date
      2016-01-09
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 遅発性筋痛発症に対するEP2受容体の関与2015

    • Author(s)
      太田大樹、片野坂公明、村瀬詩織、成宮周、水村和枝
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場・展示場(兵庫県神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Identification of silent nociceptors responsible for pathological muscle pain2015

    • Author(s)
      Matsubara T, Ota H, Ozaki N, Yamanaka A, Mizumura K, Taguchi T
    • Organizer
      第7回名古屋グローバルリトリート
    • Place of Presentation
      あいち健康プラザ(愛知県知多郡東浦町)
    • Year and Date
      2015-02-12 – 2015-02-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 遅発性筋痛におけるTRPV1, TRPV4の関与2015

    • Author(s)
      太田 大樹
    • Organizer
      第2回筋性疼痛研究会 2015年1月
    • Place of Presentation
      名古屋大学東山キャンパスES総合館(愛知県名古屋市)
    • Year and Date
      2015-01-24
    • Related Report
      2014 Research-status Report
    • Invited
  • [Remarks] 太田 大樹 - 研究者 - researchmap

    • URL

      http://researchmap.jp/hirokiota/

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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