| Project/Area Number |
26860210
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kobe University |
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Principal Investigator |
Kotani Takenori 神戸大学, 医学(系)研究科(研究院), 助教 (40455960)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 細胞間シグナル伝達 / 樹状細胞 / チロシンリン酸化・脱リン酸化 / SIRPα / CD47 / 二次リンパ組織 / ストローマ細胞 |
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| Outline of Final Research Achievements |
Signal regulatory protein α (SIRPα), an immunoglobulin superfamily protein that is expressed predominantly in dendritic cells (DCs) or macrophages, mediates cell-cell signaling by interacting with its ligand CD47, another immunoglobulin superfamily protein. In this study, I showed that mice lacking SIRPα specifically in DCs manifested a marked reduction of CD4-positive conventional DCs in the secondary lymphoid organs, as well as of Langerhans cells in the epidermis. Thus, these findings suggest that SIRPα on DCs is indispensable for homeostasis of DCs in the secondary lymphoid organs and skin.
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