Identification and characterization of novel neural crest genes involved in tumor progression
| Project/Area Number |
26860221
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
SATOW Reiko 東京薬科大学, 生命科学部, 助教 (90469966)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | メラノーマ / 神経冠 / 薬剤耐性 / Eカドヘリン / 神経冠形成遺伝子 |
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| Outline of Final Research Achievements |
To identify genes involved in tumor progression among genes essential for neural crest development, we performed siRNA-mediated screening. We showed that one of the identified genes is highly expressed in human melanoma tissues compared with benign nevi and enhances melanoma growth, survival, metastasis, and drug resistance. The identified gene contributed to melanoma drug resistance by enhancing FAK and Stat3 phosphorylation. These data indicated that the identified gene as novel molecular target of melanoma.
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Report
(3 results)
Research Products
(3 results)
