Ribosomal RNA gene mutation in Human Malignancies
Project/Area Number |
26860233
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Human pathology
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Research Institution | Niigata University |
Principal Investigator |
OHASHI Riuko 新潟大学, 医歯学系, 助教 (20447600)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | リボソーム遺伝子 / LXRα / 肺癌 / 遺伝子変異 / 遺伝子多型 / リボソームDNA / LXR / 核内受容体 |
Outline of Final Research Achievements |
In this study, we identified new somatic mutations in proximity to ribosomal RNA gene transcription start site in two cases (5%) of 40 lung cancer patients by PCR-direct sequence method. To determine the relationship between clinicopathological significance and ribosomal RNA gene mutation, sequence analysis of more patients are ongoing.
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] Frequent Germline and Somatic Single Nucleotide Variants in the Promoter Region of the Ribosomal RNA Gene in Japanese Lung Adenocarcinoma Patients2020
Author(s)
Ohashi R, Umezu H, Sato A, Abテゥ T, Kondo S, Daigo K, Sato S, Hara N, Miyashita A, Ikeuchi T, Motoyama T, Kishi M, Nagaoka T, Horiuchi K, Shiga A, Okuda S, Sekiya T, Ohtsubo A, Ichikawa K, Kagamu H, Kikuchi T, Watanabe S, Tanuma JI, Schraml P, Hamakubo T, Tsuchida M, Ajioka Y.
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Journal Title
Cells
Volume: 9
Issue: 11
Pages: 2409-2409
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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