Expression and function of non fibrillar collagen in the stroma of the invasive breast cancer

• Project/Area Number: 26860241
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Nagoya City University
• Principal Investigator: SHIOMI Kosuke 名古屋市立大学, 大学院医学研究科, 研究員 (70508043)
• Research Collaborator: YAMASHITA Yoriko
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 癌 / 乳癌 / 非線維性コラーゲン / 癌微小環境 / 間質 / コラーゲン / 乳管癌 / 線維芽細胞

Outline of Final Research Achievements

Cancer is formed of cancer cells and the stroma tissue and it became clear that the tumor microenvironment played an important role in the cancer progression. We found that types of the non-fibril collagen in a stroma were different between an invasive ductal carcinoma and non-invasive carcinoma. We analyzed the regulatory mechanism of non-fibrillar collagen expression in fibroblast. We found that the expression of type XIV collagen was downregulated by stimulation from cancer cells or surround environment, and it was suggested that regulatory mechanisms are different among type XII and XIV. We checked influences on breast cancer cell dynamics from non-fibril collagen. It did not affect the mobility and invisibility of breast cancer cells by the type of collagen which fibroblast expressed in stroma. The change of the non-fibril collagen in stroma that controlled by cancer cells might affect the dynamics of the cell except the cancer cell in cancer microenvironment.