Establishment and pathological analysis of novel model mice of systemic chronic inflammation and progeria
Project/Area Number |
26860263
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Experimental pathology
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Research Institution | Osaka University |
Principal Investigator |
Kawase Ryota 大阪大学, 医学(系)研究科(研究院), 特任研究員 (60727650)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | progranulin / 慢性炎症 / 老化 / PGRN / 炎症 / マクロファージ / 早期老化 |
Outline of Final Research Achievements |
We revealed that Progranulin (PGRN)・ApoE double KO mice (DKO) died significantly earlier than ApoE KO and often suffered joint swelling and dermatitis, which is considered to be the manifestations of chronic inflammation. Therefore, we hypothesize that DKO might be novel model mice of systemic inflammation and progeria. PGRN have been already reported to bind TNF receptors (TNFRs) and exert anti-inflammatory effects. We find possibility of another pathway other than TNFRs in TNFR KO mice. We also revealed that macrophage-derived PGRN plays important athero-protective roles by using bone marrow transplantation method. And we found that PGRN binding HDL has an anti-oxidative effect. Taken together, PGRN might play essential roles in anti-inflammation and successful aging.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Progranulin plays crucial roles in preserving bone mass by inhibiting TNF-α-induced osteoclastogenesis and promoting osteoblastic differentiation in mice2015
Author(s)
Noguchi T, Ebina K, Hirao M, Kawase R, Ohama T, Yamashita S, Morimoto T, Koizumi K, Kitaguchi K, Matsuoka H, Kaneshiro S, Yoshikawa H
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Journal Title
Biochem Biophys Res Commun.
Volume: 465(3)
Pages: 638-643
Related Report
Peer Reviewed
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[Journal Article] Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice.2015
Author(s)
Nakatani K, Watabe T, Masuda D, Imaizumi M, Shimosegawa E, Kobayashi T, Sairyo M, Zhu Y, Okada T, Kawase R, Nakaoka H, Naito A, Ohama T, Koseki M, Oka T, Akazawa H, Nishida M, Komuro I, Sakata Y, Hatazawa J, Yamashita S
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Journal Title
Metabolism
Volume: 64(9)
Pages: 1165-1174
Related Report
Peer Reviewed
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[Presentation] Roles of Progranulin in the stabilization of vulnerable coronary arterial plaques2015
Author(s)
Ryota Kawase, Tohru Ohama, Masaya Morita , Yuma Kurozumi , Noritoshi Ito , Masami Sairyo, Takeshi Okada, Hajime Nakaoka, Kazuhiro Nakatani, Daisaku Masuda, Masahiro Koseki , Makoto Nishida, Hirotaka Sawano , Yasuharu Doi , Yasushi Sakata and Shizuya Yamashita
Organizer
第47回 日本動脈硬化学会総会
Place of Presentation
仙台
Year and Date
2015-07-09
Related Report
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[Presentation] Roles of an HDL-associated Anti-inflammatory Protein, Progranulin, in Acute Coronary Syndrome2015
Author(s)
Ryota Kawase, Tohru Ohama, Masaya Morita, Yuma Kurozumi, Noritoshi Ito, Masami Sairyo, YingHong Zhu, Takeshi Okada, Hajime Nakaoka, Kazuhiro Nakatani, Daisaku Masuda, Masahiro Koseki, Makoto Nishida, Yukihiko Ueda, Hirotaka Sawano, Yasuharu Doi, Yasushi Sakata and Shizuya Yamashita
Organizer
第17回 国際動脈硬化学会
Place of Presentation
オランダ
Year and Date
2015-05-23
Related Report
Int'l Joint Research
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[Presentation] Roles of an HDL-associated Anti-inflammatory Protein, Progranulin, in Acute Coronary Syndrome2015
Author(s)
Ryota Kawase, Tohru Ohama, Masaya Morita, Yuma Kurozumi, Noritoshi Ito, Masami Sairyo, YingHong Zhu, Takeshi Okada, Hajime Nakaoka, Kazuhiro Nakatani, Daisaku Masuda, Masahiro Koseki, Makoto Nishida, Hirotaka Sawano, Yasuharu Doi, Yasushi Sakata and Shizuya Yamashita
Organizer
第79回 日本循環器学会総会
Place of Presentation
大阪
Year and Date
2015-04-24
Related Report