| Project/Area Number |
26860285
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Kyoto University |
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Principal Investigator |
Aikawa Chihiro 京都大学, 医学(系)研究科(研究院), 助教 (70725499)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 分泌タンパク質 / 42 kDa protein / A群レンサ球菌 / Group A streptococcus / 感染動態 / オートファジー / 細胞内生存 |
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| Outline of Final Research Achievements |
Group A Streptococcus (GAS) possesses a number of secreted proteins, but their precise roles at different infection stages including host cell adhesion, invasion and intracellular survival are largely unknown. Here, we identified 42 kDa protein as a novel candidate secreted protein of GAS regulating bacterial cell adhesion/invasion, autophagy and cytotoxicity. Our results suggests that 42 kDa protein is an Important clue in evaluating the infection status of GAS in host cells at different stages of infection.
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