Analysis of bacteria-host neuron interactions to study the mechanism of whooping cough
| Project/Area Number |
26860286
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 百日咳 / 感覚神経 / カルシウムイメージング / 咳発作 |
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| Outline of Final Research Achievements |
Whooping cough is a respiratory infectious disease caused by Bordetella pertussis. Infection results in a severe cough illness, however the mechanism is still uncovered. We hypothesized that direct stimulation of host tracheal sensory neuron by B. pertussis induce coughing during infection. To investigate this, we performed calcium imaging analysis to examine the interaction between bacterial lysates and rat sensory neurons. However, the specific neural stimulation by coughing-inducing bacterial lysates was not identified. In this work, we could not analyze the host neuron-bacteria interaction.
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Report
(3 results)
Research Products
(7 results)
