Investigation of intrinsic antiviral factors against viroporins
Project/Area Number |
26860307
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Virology
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Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
SUZUKI Tadaki 国立感染症研究所, 感染病理部, 室長 (30527180)
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Research Collaborator |
TAKAHASHI Kenta 国立感染症研究所, 感染病理部, 主任研究官
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | ヴァイロポリン / ポリオーマウイルス / JCウイルス / 内因性ウイルス感染制御因子 / JCPyV / 進行性多巣性白質脳症 / JCV / 細胞障害 |
Outline of Final Research Achievements |
Viroporins are small and hydrophobic viral proteins that assemble into ion-channel like structures on host cell membranes. Expression of viroporins in viral replicaiton can increase the infected cell’s membrane permeability and the secretion of progeny virions. JC virus (JCV), belongs to polyomavirus family, is the causative agent of progressive multifocal leukoenchephalopathy (PML). Recently we have demonstrated that JCV Agno acts as a JCV viroporin. Furthermore, we also demonstrate that an interaction of Agno with a host cellular protein modulates the viroporin activity of Agno. These findings indicate the host cellular protein can detect JCV infection and play a role in restriction of viral replication. These proteins, which are described as intrinsic antiviral factors, interact directly with viral components and suppress viral replication directly. In this study, we explored intrinsic antiviral factors against polyomavirus viroporins.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Neuropathogenicity of Two Saffold Virus Type 3 Isolates in Mouse Models.2016
Author(s)
Kotani O, Naeem A, Suzuki T, Iwata-Yoshikawa N, Sato Y, Nakajima N, Hosomi T, Tsukagoshi H, Kozawa K, Hasegawa H, Taguchi F, Shimizu H, Nagata N.
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Journal Title
PLOS One
Volume: 11
Issue: 2
Pages: 1-29
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Relationship of the quaternary structure of human secretory IgA to neutralization of influenza virus.2015
Author(s)
Suzuki T, Kawaguchi A, Ainai A, Tamura S, Ito R, Multihartina P, Setiawaty V, Pangesti KN, Odagiri T, Tashiro M, Hasegawa H.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 112(25)
Issue: 25
Pages: 7809-14
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Establishment of a panel of in-house polyclonal antibodies for the diagnosis of enterovirus infections2014
Author(s)
Kotani O, Iwata-Yoshikawa N, Suzuki T, Sato Y, Nakajima N, Koike S, Iwasaki T, Sata T, Yamashita T, Minagawa H, Taguchi F, Hasegawa H, Shimizu H, Nagata N
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Journal Title
Neuropathology
Volume: 35
Issue: 2
Pages: 107-121
DOI
Related Report
Peer Reviewed
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[Journal Article] Two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) in Japan: A pathognomonic histological feature and unique complication of SFTS.2014
Author(s)
Hiraki T, Yoshimitsu M, Suzuki T, Goto Y, Higashi M, Yokoyama S, Tabuchi T, Futatsuki T, Nakamura K, Hasegawa H, Saijo M, Kakihana Y, Arima N, Yonezawa S.
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Journal Title
Pathol Int.
Volume: 64(11)
Issue: 11
Pages: 569-75
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The Host Protease TMPRSS2 Plays a Major Role in In Vivo Replication of Emerging H7N9 and Seasonal Influenza Viruses2014
Author(s)
Sakai K, Ami Y, Tahara M, Kubota T, Anraku M, Abe M, Nakajima N, Sekizuka T, Shirato K, Suzaki Y, Ainai A, Nakatsu Y, Kanou K, Nakamura K, Suzuki T, Komase K, Nobusawa E, Maenaka K, Kuroda M, Hasegawa H et al
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Journal Title
J Virol
Volume: 88
Issue: 10
Pages: 5608-5616
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 本邦発症の進行性多巣性白質脳症患者サーベイランスの現状と課題 – 厚労科研PML研究班PMLサーベイランス報告 –.2015
Author(s)
三浦義治, 中道一生, 岸田修二, 西條政幸, 高橋健太, 鈴木忠樹, 三條伸夫, 阿江竜介, 澤洋文, 奴久妻聡一, 原由紀子, 雪竹基弘, 濱口毅, 水澤英洋, 山田正仁.
Organizer
第20回日本神経感染症学会総会・学術大会
Place of Presentation
長野
Year and Date
2015-10-22
Related Report
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