| Project/Area Number |
26860335
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Kumamoto University |
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Principal Investigator |
Akahoshi Tomohiro 熊本大学, エイズ学研究センター, 特定事業研究員 (10635783)
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| Research Collaborator |
GATANAGA Hiroyuki 国立国際医療研究センター, エイズ治療・研究開発センター
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | HIV-1 / CTL / 逃避変異 / 変異の蓄積 / HIV-1増殖制御 / 増殖制御 |
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| Outline of Final Research Achievements |
It has been suggested that circulation of mutant HIV-1 which had acquired mutations to escape from immune pressure of HIV-1-specific cytotoxic T lymphocytes (CTL) was associated with more rapid disease progression in recent HIV-1-infected individuals than that in previous ones. However, why does the disease still gradually progress rather than more rapidly? To address this issue, I investigated presence of HIV-1-specific CTLs recognizing mutant HIV-1 in context of CTL epitopes which were observed low frequent mutations in a cohort of treatment-naive chronically HIV-1-infected Japanese. As a result, I found that HIV-1-specific CTLs were induced before/after emergence of mutant HIV-1, which CTLs had an ability to recognize mutant viruses and/or to suppress replication of mutant viruses. This result suggests that CTLs having the ability to suppress mutant viruses contribute to a delay of the disease progression.
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