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Autoantibodies in connective tissue disease with pulmonary hypertension possibly play a role in the pathogenesis.

Research Project

Project/Area Number 26860362
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Laboratory medicine
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Kato Yuko  東京医科歯科大学, 保健衛生学研究科, 助教 (50580875)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords自己抗体
Outline of Final Research Achievements

The process of pulmonary vascular remodeling in pulmonary arterial hypertension in connective tissue disease largely depends on migration of pulmonary artery smooth muscle cells. Since autoantibodies in connective tissue disease patients were reported involving in cell migration, we tested whether auto-antibodies in connective tissue disease patients can play a role in the pathogenesis.
IgG from patients significantly increased migration of pulmonary artery smooth muscle cells, which was greater in the patients with pulmonary arterial hypertension than those without it. Moreover, the antibodies bound to enolase 1, and the titer of IgG anti- enolase 1 antibodies was higher in the patients with pulmonary arterial hypertension than those without it. These results suggest that Anti-enolase 1 antibodies in connective tissue disease patients with pulmonary arterial hypertension may induce migration of pulmonary artery smooth muscle cells, and possibly play a pivotal role in the pathogenesis.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2016 2015 2014

All Journal Article (1 results) Presentation (3 results)

  • [Journal Article] 膠原病患者における肺動脈平滑筋細胞の増殖を促進する自己抗体の検出2015

    • Author(s)
      石毛里奈、加藤優子、芝田和弥、笹本健太、窪田哲朗
    • Journal Title

      臨床検査学教育

      Volume: 7 Pages: 80-81

    • Related Report
      2014 Research-status Report
  • [Presentation] Anti-enolase 1 autoantibodies in SLE with pulmonary hypertension induce migration of pulmonary artery smooth muscle cells.2016

    • Author(s)
      Yuko Kato, Kazuya Shibata, Rina Ishige, Tetsuo Kubota.
    • Organizer
      Annual General Assembly and Scientific Meeting of the Japan College of Rheumatology
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-04-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] The role of Epac1 in the regulatory mechanisms of vascular smooth muscle cell migration and neointimal formation.2016

    • Author(s)
      Yuko Kato, Utako Yokoyama, Yoshihiro Ishikawa.
    • Organizer
      The 93th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      札幌コンベンションセンター (北海道札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 膠原病患者における肺動脈平滑筋細胞の増殖を促進する自己抗体の検出2014

    • Author(s)
      石毛里奈、加藤優子、芝田和弥、笹本健太、窪田哲朗
    • Organizer
      第9回日本臨床検査学教育学会学術集会
    • Place of Presentation
      東京 大田区産業プラザ
    • Year and Date
      2014-08-20 – 2014-08-22
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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