Elucidation of the irregular erythrocyte antibodies-related delayed hemolytic transfusion reaction - Promotion of the prospective collaborative study -

• Project/Area Number: 26860366
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Fujihara Harumi 浜松医科大学, 医学部附属病院, 臨床検査技師 (50643350)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 赤血球不規則抗体 / 輸血 / 前方向多施設共同研究 / 遅発性溶血性輸血副作用 / 不規則抗体 / 全方向多施設共同研究

Outline of Final Research Achievements

The registrant of this study was 331 cases. 257 cases performed irregular erythrocyte antibodies after transfusion or parturition (78%). The positive conversions were identified 4 cases (3.3%) in RBC transfusion group and no cases in parturition group. The irregular erythrocyte antibodies in these 4 cases were as follows : anti-E, anti-Jka, anti-C, anti-Lea. As for the gender, 3 cases were women. As for the effect of pregnancy history, 2 cases were having pregnancy history and 1 case was primiparity.
The problem of the future pilot study refines a population when we calculate the positive conversions ratio of the irregular erythrocyte antibody. The true positive conversions ratio of each irregularity erythrocyte antibody is detected by limiting the population which should follow. After the review of the population, we recruit participating institutions from an irregular erythrocyte antibody research group and conduct the pilot study of the collaborative study.

Research Products

• [Journal Article] Involvement of transfusion unit staff in the informed consent process (2016)
  • Author(s): Furumaki H, Fujihara H, Yamada C, Watanabe H, Shibata H, Kaneko M, Nagai S, Ishizuka K, Tsuzuki M, Adachi M, Takeshita A
  • Journal Title: Transfus Apher Sci Volume: 54(1) Issue: 1 Pages: 150-157
  • DOI: 10.1016/j.transci.2015.12.002
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Evaluation of the in-hospital hemovigilance by introduction of the information technology–based system (2015)
  • Author(s): Harumi Fujihara, Chiaki Yamada, Hiroaki Furumaki, Seiya Nagai, Hiroki Shibata, Keiko Ishizuka, Hiroko Watanabe, Makoto Kaneko, Miwa Adachi, and Akihiro Takeshita
  • Journal Title: Transfusion Volume: 55(12) Issue: 12 Pages: 2898-2094
  • DOI: 10.1111/trf.13228
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 採血患者誤認を契機とした検体照合システムの導入と技師の病棟採血への参加－臨床側との連携をめざして－ (2014)
  • Author(s): 永井聖也, 山田千亜希, 藤原晴美, 渡邊弘子, 金子誠, 芝田大樹, 古牧宏啓, 石塚恵子, 清水大輔, 安達美和, 竹下明裕
  • Journal Title: 臨床病理 Volume: 62 Pages: 749-754
  • Peer Reviewed
• [Presentation] 高校生の体格が献血行動に及ぼす影響 (2016)
  • Author(s): 保坂侑里,藤原晴美, 芝田大樹, 榛葉隆人, 都築茉里子, 石塚恵子, 古牧宏啓, 山田千亜希, 渡邊弘子, 金子誠, 室井一男, 竹下明裕
  • Organizer: 第64回 日本輸血・細胞治療学会 総会
  • Place of Presentation: 国立京都国際会館（京都市）
  • Year and Date: 2016-04-28
• [Presentation] 高校生を対象とした献血に関する意識調査 献血の契機となったこと (2016)
  • Author(s): 榛葉隆人, 藤原晴美, 保坂侑里, 芝田大樹, 都築茉里子, 石塚恵子, 古牧宏啓, 山田千亜希, 渡邊弘子, 金子誠, 室井一男, 竹下明裕
  • Organizer: 第64回 日本輸血・細胞治療学会 総会
  • Place of Presentation: 国立京都国際会館（京都市）
  • Year and Date: 2016-04-28
• [Presentation] 術中迅速検査の導入による適正輸血の推進に果たす輸血部門の役割 (2016)
  • Author(s): 山田千亜希, 藤原晴美, 渡邊弘子, 金子誠, 芝田大樹, 古牧宏啓, 石塚恵子, 都築茉里子, 榛葉隆人, 保坂侑里, 竹下明裕
  • Organizer: 第64回 日本輸血・細胞治療学会 総会
  • Place of Presentation: 国立京都国際会館（京都市）
  • Year and Date: 2016-04-28
• [Presentation] アルブミン製剤以外の血漿分画製剤の一元管理による適正使用の推進 (2016)
  • Author(s): 古牧宏啓, 山田千亜希, 芝田大樹, 石塚恵子, 榛葉隆人, 保坂侑里, 都築茉里子, 藤原晴美, 渡邊弘子, 金子誠, 竹下明裕
  • Organizer: 第64回 日本輸血・細胞治療学会 総会
  • Place of Presentation: 国立京都国際会館（京都市）
  • Year and Date: 2016-04-28
• [Presentation] 高校生からの献血推進への提案 (2016)
  • Author(s): 芝田大樹, 藤原晴美, 保坂侑里, 榛葉隆人, 都築茉里子, 石塚恵子, 古牧宏啓, 山田千亜希, 渡邊弘子, 金子誠, 室井一男, 竹下明裕
  • Organizer: 第64回 日本輸血・細胞治療学会 総会
  • Place of Presentation: 国立京都国際会館（京都市）
  • Year and Date: 2016-04-28
• [Presentation] High level of understanding for blood transfusions in patients can be achieved by expert staff from the transfusion unit (2015)
  • Author(s): Furumaki H, Yamada C, Fujihara H, Watanabe H, Shibata H, Nagai S, Ishizuka K, Kaneko M, Tuzuki M, Adachi M, Takeshita A
  • Organizer: European Hematology Association
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2015-06-11
• [Presentation] インフォームド・コンセント取得に係るスタッフ間相互チェックの重要性 (2015)
  • Author(s): 古牧宏啓, 安達美和, 山田千亜希, 藤原晴美, 渡邊弘子, 金子誠, 芝田大樹, 永井聖也, 石塚恵子, 都築茉里子, 竹下明裕
  • Organizer: 日本輸血・細胞治療学会
  • Place of Presentation: 新宿
  • Year and Date: 2015-05-28
• [Presentation] 不規則抗体陽性患者に対する赤血球輸血の実態調査について (2015)
  • Author(s): 山田千亜希, 渡辺弘子, 都築茉里子, 永井聖也, 古牧宏啓, 芝田大樹, 藤原晴美, 石塚恵子,金子誠, 竹下明裕
  • Organizer: 第64回 日本輸血・細胞治療学会東海支部例会
  • Place of Presentation: 名古屋市（桑山ビル）
  • Year and Date: 2015-02-07
• [Presentation] Timely monitoring including of hematological tests on the spot and intervention of transfusion unit decrease perioperative and postoperative bleeding (2014)
  • Author(s): Chiaki Yamada, Hiroaki Furumaki, Harumi Fujihara, Hiroki Shibata, Seiya Nagai, Keiko Ishizuka, Mariko Tsuzuki, Makoto Kaneko, Hiroko Watanabe, Miwa Adachi, Akihiro Takeshita
  • Organizer: 2014 AABB annual meeting
  • Place of Presentation: Philadelphia, US
  • Year and Date: 2014-10-25
• [Presentation] The image monitoring of operating rooms improves practices in transfusion medicine; recent result (2014)
  • Author(s): Hiroaki Furumaki, Chiaki Yamada, Hiroko Watanabe, Harumi Fujihara, Hiroki Shibata, Seiya Nagai, Keiko Ishizuka, Makoto Kaneko, Shimizu Daisuke, Miwa Adachi, Akihiro Takeshita
  • Organizer: 33rd International Congress of the International Society of Blood Transfusion
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2014-06-04
• [Presentation] 輸血部門によるインフォームド・コンセント取得への関わりとその有用性 (2014)
  • Author(s): 古牧宏啓, 山田千亜希, 藤原晴美, 渡邊弘子, 金子誠, 芝田大樹, 永井聖也, 石塚恵子, 都築茉里子, 清水大輔, 安達美和, 竹下明裕
  • Organizer: 第62回 日本輸血・細胞治療学会 総会
  • Place of Presentation: 奈良市（奈良県文化会館・奈良県新公会堂・東大寺総合文化センター）
  • Year and Date: 2014-05-15
• [Presentation] 輸血効果の評価に関する輸血部門の取り組みとその効果 (2014)
  • Author(s): 山田千亜希, 藤原晴美, 芝田大樹, 古牧宏啓, 永井聖也, 石塚恵子, 金子誠, 渡邊弘子, 清水大輔, 竹下明裕
  • Organizer: 第62回 日本輸血・細胞治療学会 総会
  • Place of Presentation: 奈良市（奈良県文化会館・奈良県新公会堂・東大寺総合文化センター）
  • Year and Date: 2014-05-15