| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Circulating micro (mi)RNA profiles are influenced by various medical conditions, and miRNAs have been examined as potential biomarkers for cancer, cardiovascular disease, and diabetes. However, few studies have investigated whether circulating miRNAs and life style factors, such as cigarette smoking and drinking, are correlated. Our aim was to determine the association between smoking status and expression of various miRNAs in a Japanese population sample. We found that life style factors is associated with elevated expression of various serum miRNAs.
Our results suggest that it is necessary to consider the confounding effect caused by lifestyle when evaluating expression of serum miRNAs for diagnosing pathological conditions.
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