Nutritional metabolome profiling reveals biomarkers for visceral fat accumulation

• Project/Area Number: 26860421
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Keio University
• Principal Investigator: KURIHARA Ayako 慶應義塾大学, 医学部, 助教 (40645470)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: メタボロームプロファイリング / 肥満 / メタボローム解析 / 内臓脂肪蓄積 / 栄養疫学研究 / 栄養疫学 / 内臓脂肪測定 / 食事調査 / 24時間蓄尿

Outline of Final Research Achievements

According to WHO, population of overweight or obesity have been increasing in worldwide, about half population already have been them. Even if one have overweight, NCD are tend to appear or develop early among Japanese. However few biomarkers of obesity or overweight are known.
We performed both two metabolome profiling, 32 urine samples and 1973 plasma samples, collected from residents in Tsuruoka City, identifying and quantifying 77 urine and 75 plasma metabolome. Both urine and plasma metabolome were different by obesity and some biomarkers for prevention were suggested. This study suggests that both urine and plasma metabolome profiling is useful for early prevention for obesity.

Research Products

• [Journal Article] Profiling of plasma metabolites in postmenopausal women with metabolic syndrome. (2016)
  • Author(s): Iida Miho, Harada Sei, Kurihara Ayako, Fukai Kota et al.
  • Journal Title: Menopause Volume: 23.7 Issue: 7 Pages: 749-758
  • DOI: 10.1097/gme.0000000000000630
  • Peer Reviewed / Open Access
• [Journal Article] Metabolomic profiling reveals novel biomarkers of alcohol intake and alcohol-induced liver injury in community-dwelling men. (2016)
  • Author(s): Harada S, Takebayashi T, Kurihara A, Akiyama M, Suzuki A, Hatakeyama Y, Sugiyama D, Kuwabara K, Takeuchi A, Okamura T, Nishiwaki Y, Tanaka T, Hirayama A, Sugimoto M, Soga T, Tomita M.
  • Journal Title: Environ Health Prev Med. Volume: 21(1) Issue: 1 Pages: 18-26
  • DOI: 10.1007/s12199-015-0494-y
  • NAID: 210000000441
  • Peer Reviewed / Open Access
• [Presentation] 地域在住者の代謝プロファイリングと肥満による代謝経路変化 (2015)
  • Author(s): 栗原綾子、原田成、武林亨 、岡村智教 、冨田勝
  • Organizer: 第62回日本栄養改善学会学術総会
  • Place of Presentation: 福岡国際会議場・福岡サンパレスホテル（福岡県福岡市博多区）
  • Year and Date: 2015-09-24
• [Presentation] 地域在住者における肥満と血漿中メタボロームの関連 (2014)
  • Author(s): 栗原綾子
  • Organizer: 第61回日本栄養改善学会学術総会
  • Place of Presentation: 第61回日本栄養改善学会学術総会（横浜）
  • Year and Date: 2014-08-20 – 2014-08-22
• [Remarks] http://tsuruoka-mirai.net/