| Project/Area Number |
26860423
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Niigata University of Health and Welfare |
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Principal Investigator |
Asai Takao 新潟医療福祉大学, 医療技術学部, 講師 (60612736)
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| Research Collaborator |
TSUCHIYA Yasuo 新潟大学, 医歯学総合研究科, 客員研究員 (60334679)
Sergio Báez Hospital Dr. Sótero del Río
Andrea Tello Martínez Hospital Dr. Sótero del Río
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 胆嚢がん / 遺伝要因 / 遺伝子多型 / SNPジェノタイピング / チリ / 予後予測 / 生存期間 / 予後規定因子 / 国際情報交換 |
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| Outline of Final Research Achievements |
Genetic factors may contribute to the survival of gallbladder cancer (GBC) patients. We aimed to identify SNPs involved in the survival times of GBC patients. A total of 96 GBC patients in Chile were analyzed using a Cancer SNP Panel (Illumina Inc.) that contained 1,421 SNPs in 408 cancer-related genes. SNPs associated with the cancer-specific survival were screened by log-rank test. Six SNPs were identified to have statistically significant association with cancer-specific survival. The cancer-specific survival times of patients grouped according to the number of risk genotypes of 6 SNPs differed significantly (0-1 vs 2-3 vs 4-6 risk genotypes; P=3.05x10-10). The number of risk genotypes was independently associated with survival of GBC patients in a multivariate analysis that included age and stage (P=2.26x10-8).
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